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10.1016/j.ceb.2007.11.009 http://scihub22266oqcxt.onion/10.1016/j.ceb.2007.11.009 18194854!2720100!18194854     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Cell+Biol 2008 ; 20 (1): 48-52 Nephropedia Template TP {{tp|p=18194854|t=2008. Cilia orientation and the fluid mechanics of development |pdf=|usr=}}{{18194854}} gab.com Text Cilia orientation and the fluid mechanics of development JO: Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=18194854 #FOAvip Motile cilia produce large-scale fluid flows crucial for development and physiology. Defects in ciliary motility cause a range of disease symptoms including bronchiectasis, hydrocephalus, and situs inversus. However, it is not enough for cilia to be motile and generate a flow -- the flow must be driven in the proper direction. Generation of properly directed coherent flow requires that the cilia are properly oriented relative to tissue axes. Genetic, molecular, and ultrastructural studies have begun to suggest pathways linking cilia orientation to planar cell polarity (PCP) and other long-range positional cues and also suggest that cilia-driven flow can itself play a causal role in orienting the cilia that create it. Errors in cilia orientation have been observed in human ciliary disease patients, suggesting that orientation defects may constitute a novel class of ciliopathies with a distinct etiology at the cell biological level. Twit Text FOAVip Cilia orientation and the fluid mechanics of development ????Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=18194854 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18194854 #FOAvip English Wikipedia <ref>{{Cite pmid|18194854}}</ref> Cilia orientation and the fluid mechanics of development #MMPMID18194854 Marshall WF; Kintner C Curr Opin Cell Biol 2008[Feb]; 20 (1): 48-52 PMID18194854show ga Motile cilia produce large-scale fluid flows crucial for development and physiology. Defects in ciliary motility cause a range of disease symptoms including bronchiectasis, hydrocephalus, and situs inversus. However, it is not enough for cilia to be motile and generate a flow -- the flow must be driven in the proper direction. Generation of properly directed coherent flow requires that the cilia are properly oriented relative to tissue axes. Genetic, molecular, and ultrastructural studies have begun to suggest pathways linking cilia orientation to planar cell polarity (PCP) and other long-range positional cues and also suggest that cilia-driven flow can itself play a causal role in orienting the cilia that create it. Errors in cilia orientation have been observed in human ciliary disease patients, suggesting that orientation defects may constitute a novel class of ciliopathies with a distinct etiology at the cell biological level. |*Cell Polarity[MESH] |*Embryonic Development[MESH] |Animals[MESH] |Cilia/*metabolism[MESH] |Humans[MESH]Cilia orientation and the fluid mechanics of development (epmc).pdf DeepDyve Pubget Overpricing