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  • Intraflagellar transport motors in cilia: moving along the cell s antenna #MMPMID18180368
  • Scholey JM
  • J Cell Biol 2008[Jan]; 180 (1): 23-9 PMID18180368show ga
  • Intraflagellar transport (IFT), the motor-dependent movement of IFT particles along the axoneme, is critical for the assembly, maintenance, and function of motile and sensory cilia, and, consequently, this process underlies ciliary motility, cilium-based signaling, and ciliopathies. Here, I present my perspective on IFT as a model system for studying motor-driven cargo transport. I review evidence that kinesin-2 motors physically transport IFT particles as cargo and hypothesize that several accessory kinesins confer cilia-specific functions by augmenting the action of the two core IFT motors, kinesin-2 and dynein 1b, which assemble the cilium foundation.
  • |Animals[MESH]
  • |Biological Transport/physiology[MESH]
  • |Chlamydomonas/metabolism/ultrastructure[MESH]
  • |Cilia/*metabolism/ultrastructure[MESH]
  • |Dyneins/physiology[MESH]
  • |Flagella/*metabolism/ultrastructure[MESH]
  • |Kinesins/physiology[MESH]
  • |Models, Biological[MESH]

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  • suck abstract from ncbi

    23 1.180 2008