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10.1016/0304-4165(76)90361-5 http://scihub22266oqcxt.onion/10.1016/0304-4165(76)90361-5 181075!ä!181075 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 1976 ; 437 (1): 200-10 Nephropedia Template TP {{tp|p=181075|t=1976. Aflatoxin inhibition of glucocorticoid finding capacity of rat liver nuclei |pdf=|usr=}}{{181075}} gab.com Text Aflatoxin inhibition of glucocorticoid finding capacity of rat liver nuclei JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=181075 #FOAvip The effect of aflatoxin B1 on the binding capacity of rat liver cytoplasmic glucocorticoid receptors and the nuclear binding of the activated receptor complex was investigated. No alterations in the kinetics of [3H]desamethasone-cytosol receptor complex formation were noted 2 h after treatment with 1 mg/kg aflatoxin B1. However, a 33% decrease in the concentration of nuclear acceptor sites and a 24% decrease in the glucocorticoid receptor-nuclear binding equilibrium constant of dissociation was observed. This response was near maximal at 2 h and persisted for at least 26 h. Inhibition of nuclear binding capacity was directly related to aflatoxin B1 dose, with a correlation coefficient of 0.99. Actinomycin D treatment (0.1 mg/kg) resulted in a slight reduction (16%) in the concentration of nuclear acceptor sites but had no effect on the nuclear binding dissociation constant. Administration of [3H]dexamethasone to alfatoxin B1 -treated rats produced a similar pattern of glucocorticoid binding distribution in vivo to that observed in vitro. No differences in [3H]dexamethasone-cytoplasmic receptor binding between control and alfatoxin B1 -treated rats were found, whereas nuclear [3H]dexanthasone binding was reduced 34% by alfatoxin B1 -treatment. Twit Text FOAVip Aflatoxin inhibition of glucocorticoid finding capacity of rat liver nuclei ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=181075 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=181075 #FOAvip English Wikipedia <ref>{{Cite pmid|181075}}</ref> Aflatoxin inhibition of glucocorticoid finding capacity of rat liver nuclei #MMPMID181075 Kensler TW; Busby WF Jr; Davidson NE; Wogan GN Biochim Biophys Acta 1976[Jun]; 437 (1): 200-10 PMID181075show ga The effect of aflatoxin B1 on the binding capacity of rat liver cytoplasmic glucocorticoid receptors and the nuclear binding of the activated receptor complex was investigated. No alterations in the kinetics of [3H]desamethasone-cytosol receptor complex formation were noted 2 h after treatment with 1 mg/kg aflatoxin B1. However, a 33% decrease in the concentration of nuclear acceptor sites and a 24% decrease in the glucocorticoid receptor-nuclear binding equilibrium constant of dissociation was observed. This response was near maximal at 2 h and persisted for at least 26 h. Inhibition of nuclear binding capacity was directly related to aflatoxin B1 dose, with a correlation coefficient of 0.99. Actinomycin D treatment (0.1 mg/kg) resulted in a slight reduction (16%) in the concentration of nuclear acceptor sites but had no effect on the nuclear binding dissociation constant. Administration of [3H]dexamethasone to alfatoxin B1 -treated rats produced a similar pattern of glucocorticoid binding distribution in vivo to that observed in vitro. No differences in [3H]dexamethasone-cytoplasmic receptor binding between control and alfatoxin B1 -treated rats were found, whereas nuclear [3H]dexanthasone binding was reduced 34% by alfatoxin B1 -treatment. |Aflatoxins/*pharmacology[MESH] |Animals[MESH] |Cell Nucleus/drug effects/*metabolism[MESH] |Cytosol/drug effects/metabolism[MESH] |Dexamethasone/*metabolism[MESH] |Dose-Response Relationship, Drug[MESH] |Kinetics[MESH] |Liver/drug effects/*metabolism[MESH] |Male[MESH] |Rats[MESH]Aflatoxin inhibition of glucocorticoid finding capacity of rat liver n(epmc).pdf DeepDyve Pubget Overpricing