Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1146/annurev.pathmechdis.3.121806.151434 http://scihub22266oqcxt.onion/10.1146/annurev.pathmechdis.3.121806.151434 18039139/?report=reader!3653419!18039139     free     free     free       Annu+Rev+Pathol 2008 ; 3 (ä): 399-425 Nephropedia Template TP {{tp|p=18039139|t=2008. Endoplasmic reticulum stress in disease pathogenesis |pdf=|usr=}}{{18039139}} gab.com Text Endoplasmic reticulum stress in disease pathogenesis JO: Annu Rev Pathol http://www.kidney.de/pget.php?&tw=1&pmid=18039139 #FOAvip The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins, which, collectively, represent a large fraction of the total protein output of a mammalian cell. Therefore, the protein flux through the ER must be carefully monitored for abnormalities, including the buildup of misfolded proteins. Mammalian cells have evolved an intricate set of signaling pathways from the ER to the cytosol and nucleus, to allow the cell to respond to the presence of misfolded proteins within the ER. These pathways, known collectively as the unfolded protein response, are important for normal cellular homeostasis and organismal development and may also play key roles in the pathogenesis of many diseases. This review provides background information on the unfolded protein response and discusses a selection of diseases whose pathogenesis involves ER stress. Twit Text FOAVip Endoplasmic reticulum stress in disease pathogenesis ????Annu Rev Pathol http://www.kidney.de/pget.php?&tw=1&pmid=18039139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18039139 #FOAvip English Wikipedia <ref>{{Cite pmid|18039139}}</ref> Endoplasmic reticulum stress in disease pathogenesis #MMPMID18039139 Lin JH; Walter P; Yen TS Annu Rev Pathol 2008[]; 3 (ä): 399-425 PMID18039139show ga The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins, which, collectively, represent a large fraction of the total protein output of a mammalian cell. Therefore, the protein flux through the ER must be carefully monitored for abnormalities, including the buildup of misfolded proteins. Mammalian cells have evolved an intricate set of signaling pathways from the ER to the cytosol and nucleus, to allow the cell to respond to the presence of misfolded proteins within the ER. These pathways, known collectively as the unfolded protein response, are important for normal cellular homeostasis and organismal development and may also play key roles in the pathogenesis of many diseases. This review provides background information on the unfolded protein response and discusses a selection of diseases whose pathogenesis involves ER stress. |*Protein Folding[MESH] |Animals[MESH] |Endoplasmic Reticulum/chemistry/*metabolism/ultrastructure[MESH] |Humans[MESH] |Metabolism, Inborn Errors/*etiology[MESH] |Signal Transduction/physiology[MESH]Endoplasmic reticulum stress in disease pathogenesis (epmc).pdf DeepDyve Pubget Overpricing