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http://scihub22266oqcxt.onion/ 17972464!ä!17972464 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Magnes+Res 2007 ; 20 (3): 208-12 Nephropedia Template TP {{tp|p=17972464|t=2007. Chronic dietary Mg2+ deficiency induces cardiac apoptosis in the rat heart |pdf=|usr=}}{{17972464}} gab.com Text Chronic dietary Mg2+ deficiency induces cardiac apoptosis in the rat heart JO: Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=17972464 #FOAvip Severe Mg2+ deficiency provokes pro-oxidative and pro-inflammatory changes, and also has been shown to be pro-apoptotic in thymus and certain cell cultures. In this study we examined the extent that chronic severe dietary Mg2+ deficiency induces apoptosis in the heart. Sprague-Dawley rats were fed during three weeks with normal (25 mM, Mg-control) or magnesium deficient (2.25 mM, Mg-deficient) diets, after which, hearts were harvested and frozen. DNA fragmentation was examined in heart tissue sections, and while < 1% of nuclei were positive for apoptosis in Mg-control rat tissue, over 32% of nuclei gave positive for Klenow fragments in hearts from Mg-deficient rats. Caspase 3 activity measurements in heart homogenates showed a 3.9-fold increase in enzyme activity in Mg-deficient rat hearts compared to Mg-controls (p < 0.002); and furthermore, western blot analysis of cleaved PARP (caspase 3 substrate), showed a 4.6-fold increase of cleaved PARP in Mg-deficient rat hearts (p < 0.002). In summary, our data indicate that chronic Mg2+ deficiency induces apoptosis of myocardium in vivo. Twit Text FOAVip Chronic dietary Mg2+ deficiency induces cardiac apoptosis in the rat heart ????Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=17972464 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17972464 #FOAvip English Wikipedia <ref>{{Cite pmid|17972464}}</ref> Chronic dietary Mg2+ deficiency induces cardiac apoptosis in the rat heart #MMPMID17972464 Tejero-Taldo MI; Chmielinska JJ; Weglicki WB Magnes Res 2007[Sep]; 20 (3): 208-12 PMID17972464show ga Severe Mg2+ deficiency provokes pro-oxidative and pro-inflammatory changes, and also has been shown to be pro-apoptotic in thymus and certain cell cultures. In this study we examined the extent that chronic severe dietary Mg2+ deficiency induces apoptosis in the heart. Sprague-Dawley rats were fed during three weeks with normal (25 mM, Mg-control) or magnesium deficient (2.25 mM, Mg-deficient) diets, after which, hearts were harvested and frozen. DNA fragmentation was examined in heart tissue sections, and while < 1% of nuclei were positive for apoptosis in Mg-control rat tissue, over 32% of nuclei gave positive for Klenow fragments in hearts from Mg-deficient rats. Caspase 3 activity measurements in heart homogenates showed a 3.9-fold increase in enzyme activity in Mg-deficient rat hearts compared to Mg-controls (p < 0.002); and furthermore, western blot analysis of cleaved PARP (caspase 3 substrate), showed a 4.6-fold increase of cleaved PARP in Mg-deficient rat hearts (p < 0.002). In summary, our data indicate that chronic Mg2+ deficiency induces apoptosis of myocardium in vivo. |Animals[MESH] |Apoptosis/*drug effects[MESH] |Blotting, Western[MESH] |Caspase 3/metabolism[MESH] |Chronic Disease[MESH] |DNA Fragmentation/drug effects[MESH] |Dietary Supplements[MESH] |Heart/*drug effects[MESH] |Magnesium Deficiency/physiopathology[MESH] |Magnesium/*administration & dosage/metabolism[MESH] |Male[MESH] |Myocardium/cytology/*metabolism[MESH] |Poly(ADP-ribose) Polymerases/metabolism[MESH] |Rats[MESH]Chronic dietary Mg2+ deficiency induces cardiac apoptosis in the rat h(epmc).pdf DeepDyve Pubget Overpricing