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10.1099/vir.0.83170-0 http://scihub22266oqcxt.onion/10.1099/vir.0.83170-0 17947539!ä!17947539 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gen+Virol 2007 ; 88 (Pt 11): 3130-3132 Nephropedia Template TP {{tp|p=17947539|t=2007. Enhanced polymerase activity confers replication competence of Borna disease virus in mice |pdf=|usr=}}{{17947539}} gab.com Text Enhanced polymerase activity confers replication competence of Borna disease virus in mice JO: J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=17947539 #FOAvip We previously showed that mouse adaptation of cDNA-derived Borna disease virus (BDV) strain He/80(FR) was associated exclusively with mutations in the viral polymerase complex. Interestingly, independent mouse adaptation of non-recombinant He/80 was correlated with different alterations in the polymerase and mutations in the viral glycoprotein. We used reverse genetics to demonstrate that changes in the polymerase which improve enzymatic activity represent the decisive host range mutations. The glycoprotein mutations did not confer replication competence in mice, although they slightly improved viral performance if combined with polymerase mutations. Our findings suggest that the viral polymerase restricts the host range of BDV. Twit Text FOAVip Enhanced polymerase activity confers replication competence of Borna disease virus in mice ????J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=17947539 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17947539 #FOAvip English Wikipedia <ref>{{Cite pmid|17947539}}</ref> Enhanced polymerase activity confers replication competence of Borna disease virus in mice #MMPMID17947539 Ackermann A; Kugel D; Schneider U; Staeheli P J Gen Virol 2007[Nov]; 88 (Pt 11): 3130-3132 PMID17947539show ga We previously showed that mouse adaptation of cDNA-derived Borna disease virus (BDV) strain He/80(FR) was associated exclusively with mutations in the viral polymerase complex. Interestingly, independent mouse adaptation of non-recombinant He/80 was correlated with different alterations in the polymerase and mutations in the viral glycoprotein. We used reverse genetics to demonstrate that changes in the polymerase which improve enzymatic activity represent the decisive host range mutations. The glycoprotein mutations did not confer replication competence in mice, although they slightly improved viral performance if combined with polymerase mutations. Our findings suggest that the viral polymerase restricts the host range of BDV. |*Virus Replication[MESH] |Animals[MESH] |Borna Disease/mortality/virology[MESH] |Borna disease virus/enzymology/*genetics/metabolism[MESH] |Cell Line[MESH] |DNA-Directed RNA Polymerases/*genetics/*metabolism[MESH] |Mice[MESH] |Mutation[MESH]Enhanced polymerase activity confers replication competence of Borna d(epmc).pdf DeepDyve Pubget Overpricing