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10.1038/sj.ki.5002573 http://scihub22266oqcxt.onion/10.1038/sj.ki.5002573 17914352!ä!17914352 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int 2008 ; 73 (1): 52-62 Nephropedia Template TP {{tp|p=17914352|t=2008. Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking |pdf=|usr=}}{{17914352}} gab.com Text Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=17914352 #FOAvip Heparan sulfate (HS) proteoglycans by playing key roles in the leukocyte-endothelial interactions are thought to mediate inflammatory cell influx in proliferative glomerulonephritis. Here, we evaluated the specific features within glomerular endothelial HS that promote leukocyte adhesion. Mouse and human glomerular endothelial cells activated by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta increased expression of inflammatory N- and 6-O-sulfated HS domains. In addition, altered expression of HS-modifying enzymes occurred, a feature also found in mouse kidneys with anti-glomerular basement membrane disease or lupus nephritis. Inhibition of the nuclear factor (NF)-kappaB pathway repressed cytokine-induced alterations in HS and gene expression of modifying enzymes. Firm adhesion of leukocytes to activated mouse glomerular endothelial cells decreased after removal of endothelial HS or addition of sulfated heparinoids. Specific antibodies that block N- and 6-O-sulfated HS domains on activated mouse endothelial cells reduced the number of rolling and firmly adhering leukocytes under dynamic flow conditions, while they increased the average leukocyte-rolling velocity. Our study shows that N- and 6-O-sulfated domains in HS on activated glomerular endothelium are crucial for leukocyte trafficking and are possible therapeutic targets. Twit Text FOAVip Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=17914352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17914352 #FOAvip English Wikipedia <ref>{{Cite pmid|17914352}}</ref> Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking #MMPMID17914352 Rops AL; van den Hoven MJ; Baselmans MM; Lensen JF; Wijnhoven TJ; van den Heuvel LP; van Kuppevelt TH; Berden JH; van der Vlag J Kidney Int 2008[Jan]; 73 (1): 52-62 PMID17914352show ga Heparan sulfate (HS) proteoglycans by playing key roles in the leukocyte-endothelial interactions are thought to mediate inflammatory cell influx in proliferative glomerulonephritis. Here, we evaluated the specific features within glomerular endothelial HS that promote leukocyte adhesion. Mouse and human glomerular endothelial cells activated by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta increased expression of inflammatory N- and 6-O-sulfated HS domains. In addition, altered expression of HS-modifying enzymes occurred, a feature also found in mouse kidneys with anti-glomerular basement membrane disease or lupus nephritis. Inhibition of the nuclear factor (NF)-kappaB pathway repressed cytokine-induced alterations in HS and gene expression of modifying enzymes. Firm adhesion of leukocytes to activated mouse glomerular endothelial cells decreased after removal of endothelial HS or addition of sulfated heparinoids. Specific antibodies that block N- and 6-O-sulfated HS domains on activated mouse endothelial cells reduced the number of rolling and firmly adhering leukocytes under dynamic flow conditions, while they increased the average leukocyte-rolling velocity. Our study shows that N- and 6-O-sulfated domains in HS on activated glomerular endothelium are crucial for leukocyte trafficking and are possible therapeutic targets. |*Leukocyte Rolling/drug effects[MESH] |Animals[MESH] |Antibodies/pharmacology[MESH] |Cell Adhesion/drug effects[MESH] |Cell Line[MESH] |Endothelial Cells/chemistry/drug effects/immunology[MESH] |Glucuronidase/metabolism[MESH] |Heparan Sulfate Proteoglycans/analysis/genetics/*metabolism[MESH] |Humans[MESH] |Interleukin-1beta/pharmacology[MESH] |Kidney Glomerulus/chemistry/drug effects/*immunology[MESH] |Leukocytes/*immunology[MESH] |Lupus Nephritis/*immunology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |NF-kappa B/metabolism[MESH] |Protein Structure, Tertiary[MESH]Heparan sulfate domains on cultured activated glomerular endothelial c(epmc).pdf DeepDyve Pubget Overpricing