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10.1016/j.clim.2007.08.001 http://scihub22266oqcxt.onion/10.1016/j.clim.2007.08.001 17827068!ä!17827068 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2007 ; 125 (3): 328-36 Nephropedia Template TP {{tp|p=17827068|t=2007. Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia |pdf=|usr=}}{{17827068}} gab.com Text Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=17827068 #FOAvip Monocyte chemoattractant protein 1 (MCP-1) and its receptor CCR2 have been shown to play an import role in leukocyte recruitment to sites of infection and inflammation. To investigate the role of MCP-1 during infection with influenza we inoculated wild-type (WT) and MCP-1 knockout (KO) mice with a non-lethal dose of a mouse adapted strain of influenza A. Influenza infection of WT mice resulted in a profound increase in pulmonary MCP-1 levels. MCP-1 KO mice had enhanced weight loss and did not fully regain their body weight during the 14-day observation period. In addition, MCP-1 KO mice demonstrated elevated viral loads 8 days after infection, which was accompanied by reduced leukocyte recruitment into the infected lungs, primarily caused by a diminished influx of macrophages and granulocytes. Moreover, pulmonary levels of IgA were reduced in MCP-1 KO mice. The pulmonary concentrations of tumor necrosis factor-alpha, interleukin-6, macrophage inflammatory protein 2 and interferon-gamma were higher in MCP-1 KO mice. This study shows that MCP-1 contributes to an adequate protective immune response against influenza infection in mice. Twit Text FOAVip Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=17827068 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17827068 #FOAvip English Wikipedia <ref>{{Cite pmid|17827068}}</ref> Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia #MMPMID17827068 Dessing MC; van der Sluijs KF; Florquin S; van der Poll T Clin Immunol 2007[Dec]; 125 (3): 328-36 PMID17827068show ga Monocyte chemoattractant protein 1 (MCP-1) and its receptor CCR2 have been shown to play an import role in leukocyte recruitment to sites of infection and inflammation. To investigate the role of MCP-1 during infection with influenza we inoculated wild-type (WT) and MCP-1 knockout (KO) mice with a non-lethal dose of a mouse adapted strain of influenza A. Influenza infection of WT mice resulted in a profound increase in pulmonary MCP-1 levels. MCP-1 KO mice had enhanced weight loss and did not fully regain their body weight during the 14-day observation period. In addition, MCP-1 KO mice demonstrated elevated viral loads 8 days after infection, which was accompanied by reduced leukocyte recruitment into the infected lungs, primarily caused by a diminished influx of macrophages and granulocytes. Moreover, pulmonary levels of IgA were reduced in MCP-1 KO mice. The pulmonary concentrations of tumor necrosis factor-alpha, interleukin-6, macrophage inflammatory protein 2 and interferon-gamma were higher in MCP-1 KO mice. This study shows that MCP-1 contributes to an adequate protective immune response against influenza infection in mice. |Animals[MESH] |Chemokine CCL2/genetics/*immunology/metabolism[MESH] |Chemokine CXCL2/immunology/metabolism[MESH] |Flow Cytometry[MESH] |Influenza A virus/*immunology[MESH] |Interferon-gamma/immunology/metabolism[MESH] |Interleukin-6/immunology/metabolism[MESH] |Lung/immunology/metabolism[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Orthomyxoviridae Infections/*immunology/*metabolism[MESH] |Pneumonia, Viral/*immunology/*metabolism[MESH] |Tumor Necrosis Factor-alpha/immunology/metabolism[MESH]Monocyte chemoattractant protein 1 contributes to an adequate immune r(epmc).pdf DeepDyve Pubget Overpricing