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10.1002/cmdc.200700120

http://scihub22266oqcxt.onion/10.1002/cmdc.200700120
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17639998!7162357!17639998
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suck abstract from ncbi


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pmid17639998      ChemMedChem 2007 ; 2 (11): 1594-7
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  • Rapid synthesis of iminosugar derivatives for cell-based in situ screening: discovery of "hit" compounds with anticancer activity #MMPMID17639998
  • Zhang L; Sun F; Li Y; Sun X; Liu X; Huang Y; Zhang LH; Ye XS; Xiao J
  • ChemMedChem 2007[Nov]; 2 (11): 1594-7 PMID17639998show ga
  • Effective and efficacious drug screening methods are imperative in the drug discovery process. A library has been constructed efficiently and followed by in situ cell-based screening without product purification. This method led to discovery of several iminosugar derivatives with anticancer activity.[Image: see text]
  • |Antineoplastic Agents/*pharmacology[MESH]
  • |Carbohydrate Conformation[MESH]
  • |Cell Line, Tumor[MESH]
  • |Drug Screening Assays, Antitumor[MESH]
  • |Humans[MESH]


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