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10.1002/gcc.20479 http://scihub22266oqcxt.onion/10.1002/gcc.20479 17636545!7165894!17636545     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+Chromosomes+Cancer 2007 ; 46 (10): 914-28 Nephropedia Template TP {{tp|p=17636545|t=2007. Transcriptional oncogenomic hot spots in Barrett s adenocarcinomas: serial analysis of gene expression |pdf=|usr=}}{{17636545}} gab.com Text Transcriptional oncogenomic hot spots in Barrett s adenocarcinomas: serial analysis of gene expression JO: Genes Chromosomes Cancer http://www.kidney.de/pget.php?&tw=1&pmid=17636545 #FOAvip Serial analysis of gene expression (SAGE) provides quantitative and comprehensive expression profiling in a given cell population. In our efforts to define gene expression alterations in Barrett's-related adenocarcinomas (BA), we produced eight SAGE libraries and obtained a total of 457,894 expressed tags with 32,035 (6.9%) accounting for singleton tags. The tumor samples produced an average of 71,804 tags per library, whereas normal samples produced an average of 42,669 tags per library. Our libraries contained 67,200 unique tags representing 16,040 known gene symbols. Five hundred and sixty-eight unique tags were differentially expressed between BAs and normal tissue samples (at least twofold; P<or=0.05), 395 of these matched to known genes. Interestingly, the distribution of altered genes was not uniform across the human genome. Overexpressed genes tended to cluster in well-defined hot spots located in certain chromosomes. For example, chromosome 19 had 26 overexpressed genes, of which 18 mapped to 19q13. Using the gene ontology approach for functional classification of genes, we identified several groups that are relevant to carcinogenesis. We validated the SAGE results of five representative genes (ANPEP, ECGF1, PP1201, EIF5A1, and GKN1) using quantitative real-time reverse-transcription PCR on 31 BA samples and 26 normal samples. In addition, we performed an immunohistochemistry analysis for ANPEP, which demonstrated overexpression of ANPEP in 6/7 (86%) Barrett's dysplasias and 35/65 (54%) BAs. ANPEP is a secreted protein that may have diagnostic and/or prognostic significance for Barrett's progression. The use of genomic approaches in this study provided useful information about the molecular pathobiology of BAs. Twit Text FOAVip Transcriptional oncogenomic hot spots in Barrett s adenocarcinomas: serial analysis of gene expression ????Genes Chromosomes Cancer http://www.kidney.de/pget.php?&tw=1&pmid=17636545 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17636545 #FOAvip English Wikipedia <ref>{{Cite pmid|17636545}}</ref> Transcriptional oncogenomic hot spots in Barrett s adenocarcinomas: serial analysis of gene expression #MMPMID17636545 Razvi MH; Peng D; Dar AA; Powell SM; Frierson HF Jr; Moskaluk CA; Washington K; El-Rifai W Genes Chromosomes Cancer 2007[Oct]; 46 (10): 914-28 PMID17636545show ga Serial analysis of gene expression (SAGE) provides quantitative and comprehensive expression profiling in a given cell population. In our efforts to define gene expression alterations in Barrett's-related adenocarcinomas (BA), we produced eight SAGE libraries and obtained a total of 457,894 expressed tags with 32,035 (6.9%) accounting for singleton tags. The tumor samples produced an average of 71,804 tags per library, whereas normal samples produced an average of 42,669 tags per library. Our libraries contained 67,200 unique tags representing 16,040 known gene symbols. Five hundred and sixty-eight unique tags were differentially expressed between BAs and normal tissue samples (at least twofold; P |*Gene Expression Profiling[MESH] |*Gene Expression Regulation, Neoplastic[MESH] |*Transcription, Genetic[MESH] |Adenocarcinoma/*genetics/metabolism[MESH] |Barrett Esophagus/*genetics/metabolism[MESH] |Biomarkers, Tumor/*genetics/metabolism[MESH] |CD13 Antigens/genetics/metabolism[MESH] |Esophageal Neoplasms/genetics/metabolism[MESH] |Expressed Sequence Tags[MESH] |Female[MESH] |Gastric Mucosa/metabolism[MESH] |Gene Library[MESH] |Humans[MESH] |Immunoenzyme Techniques[MESH] |Intestinal Neoplasms/genetics/metabolism[MESH] |Male[MESH] |RNA, Messenger/genetics/metabolism[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |Tissue Array Analysis[MESH]Transcriptional oncogenomic hot spots in Barrett s adenocarcinomas: se(epmc).pdf DeepDyve Pubget Overpricing