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10.1016/j.ahj.2007.01.040 http://scihub22266oqcxt.onion/10.1016/j.ahj.2007.01.040 17540188!ä!17540188 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+Heart+J 2007 ; 153 (6): 891-9 Nephropedia Template TP {{tp|p=17540188|t=2007. Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes |pdf=|usr=}}{{17540188}} gab.com Text Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes JO: Am Heart J http://www.kidney.de/pget.php?&tw=1&pmid=17540188 #FOAvip Drug-induced long QT syndrome is characterized by a prolonged corrected QT interval (QTc) and increased risk of a polymorphic ventricular tachycardia known as torsade de pointes (TdP). We review mechanisms, predispositions, culprit agents, and management of this potentially fatal phenomenon. Virtually all drugs that prolong QTc block the rapid component of the delayed rectifier current (I(kr)). Some drugs prolong QTc in a dose-dependent manner, others do so at any dose. Most patients that develop drug-induced TdP have underlying risk factors. Female sex is the most common. Implicated drugs include class 1A and III antiarrhythmics, macrolide antibiotics, pentamidine, antimalarials, antipsychotics, arsenic trioxide, and methadone. Treatment for TdP includes immediate defibrillation for hemodynamic instability and intravenous magnesium sulfate. Potassium levels should be maintained in the high normal range, and all QT prolonging agents must be promptly discontinued. Twit Text FOAVip Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes ????Am Heart J http://www.kidney.de/pget.php?&tw=1&pmid=17540188 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17540188 #FOAvip English Wikipedia <ref>{{Cite pmid|17540188}}</ref> Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes #MMPMID17540188 Gupta A; Lawrence AT; Krishnan K; Kavinsky CJ; Trohman RG Am Heart J 2007[Jun]; 153 (6): 891-9 PMID17540188show ga Drug-induced long QT syndrome is characterized by a prolonged corrected QT interval (QTc) and increased risk of a polymorphic ventricular tachycardia known as torsade de pointes (TdP). We review mechanisms, predispositions, culprit agents, and management of this potentially fatal phenomenon. Virtually all drugs that prolong QTc block the rapid component of the delayed rectifier current (I(kr)). Some drugs prolong QTc in a dose-dependent manner, others do so at any dose. Most patients that develop drug-induced TdP have underlying risk factors. Female sex is the most common. Implicated drugs include class 1A and III antiarrhythmics, macrolide antibiotics, pentamidine, antimalarials, antipsychotics, arsenic trioxide, and methadone. Treatment for TdP includes immediate defibrillation for hemodynamic instability and intravenous magnesium sulfate. Potassium levels should be maintained in the high normal range, and all QT prolonging agents must be promptly discontinued. |Female[MESH] |Humans[MESH] |Long QT Syndrome/*chemically induced/diagnosis/*therapy[MESH] |Male[MESH] |Risk Factors[MESH]Current concepts in the mechanisms and management of drug-induced QT p(epmc).pdf DeepDyve Pubget Overpricing