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10.1007/s00018-007-6545-9 http://scihub22266oqcxt.onion/10.1007/s00018-007-6545-9 17372677!7079776!17372677     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2007 ; 64 (9): 1038-42 Nephropedia Template TP {{tp|p=17372677|t=2007. Genome trimming by Borna disease viruses: viral replication control or escape from cellular surveillance?|pdf=|usr=}}{{17372677}} gab.com Text Genome trimming by Borna disease viruses: viral replication control or escape from cellular surveillance JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=17372677 #FOAvip Persistence of RNA viruses is frequently associated with non-uniform terminal nucleotide deletions at both ends of the viral genome, which are believed to restrict viral replication and transcription during persistent infection. Borna disease virus (BDV), a negative strand RNA virus with no recognizable acute phase, quickly establishes persistence. We recently demonstrated that the vast majority of BDV genomes and antigenomes possess uniformly trimmed 5' termini, even if the virus is recovered from complementary DNA encoding a hypothetical full-length viral genome. Here we discuss different mechanisms which might lead to the selective 5'-terminal trimming of the BDV genome and subsequent retrieval of the lost genetic information. We further discuss possible benefits of genome trimming in the light of recent findings that terminal RNA structures are recognized by intracellular sensors which trigger innate immunity. We hypothesize that 5'-terminal genome trimming might represent a smart strategy of BDV to evade the antiviral host response. Twit Text FOAVip Genome trimming by Borna disease viruses: viral replication control or escape from cellular surveillance ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=17372677 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17372677 #FOAvip English Wikipedia <ref>{{Cite pmid|17372677}}</ref> Genome trimming by Borna disease viruses: viral replication control or escape from cellular surveillance? #MMPMID17372677 Schneider U; Martin A; Schwemmle M; Staeheli P Cell Mol Life Sci 2007[May]; 64 (9): 1038-42 PMID17372677show ga Persistence of RNA viruses is frequently associated with non-uniform terminal nucleotide deletions at both ends of the viral genome, which are believed to restrict viral replication and transcription during persistent infection. Borna disease virus (BDV), a negative strand RNA virus with no recognizable acute phase, quickly establishes persistence. We recently demonstrated that the vast majority of BDV genomes and antigenomes possess uniformly trimmed 5' termini, even if the virus is recovered from complementary DNA encoding a hypothetical full-length viral genome. Here we discuss different mechanisms which might lead to the selective 5'-terminal trimming of the BDV genome and subsequent retrieval of the lost genetic information. We further discuss possible benefits of genome trimming in the light of recent findings that terminal RNA structures are recognized by intracellular sensors which trigger innate immunity. We hypothesize that 5'-terminal genome trimming might represent a smart strategy of BDV to evade the antiviral host response. |*Genome, Viral[MESH] |Base Sequence[MESH] |Borna Disease/genetics[MESH] |Borna disease virus/*genetics/physiology[MESH] |Humans[MESH] |RNA Viruses/genetics[MESH] |RNA, Viral/genetics[MESH]Genome trimming by Borna disease viruses: viral replication control or(epmc).pdf DeepDyve Pubget Overpricing