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10.1042/BJ20061297

http://scihub22266oqcxt.onion/10.1042/BJ20061297
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suck abstract from ncbi


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pmid17302560      Biochem+J 2007 ; 404 (2): 197-206
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  • Regulation of oncogenic transcription factor hTAF(II)68-TEC activity by human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) #MMPMID17302560
  • Kim S; Lee J; Kim J
  • Biochem J 2007[Jun]; 404 (2): 197-206 PMID17302560show ga
  • Tumour-specific chromosomal rearrangements are known to create chimaeric products with the ability to generate many human cancers. hTAF(II)68-TEC (where hTAF(II)68 is human TATA-binding protein-associated factor II 68 and TEC is translocated in extraskeletal chondrosarcoma) is such a fusion product, resulting from a t(9;17) chromosomal translocation found in extraskeletal myxoid chondrosarcomas, where the hTAF(II)68 NTD (N-terminal domain) is fused to TEC protein. To identify proteins that control hTAF(II)68-TEC function, we used affinity chromatography on immobilized hTAF(II)68 (NTD) and MALDI-TOF (matrix-assisted laser-desorption ionization-time-of-flight) MS and isolated a novel hTAF(II)68-TEC-interacting protein, GAPDH (glyceraldehyde-3-phosphate dehydrogenase). GAPDH is a glycolytic enzyme that is also involved in the early steps of apoptosis, nuclear tRNA export, DNA replication, DNA repair and transcription. hTAF(II)68-TEC and GAPDH were co-immunoprecipitated from cell extracts, and glutathione S-transferase pull-down assays revealed that the C-terminus of hTAF(II)68 (NTD) was required for interaction with GAPDH. In addition, three independent regions of GAPDH (amino acids 1-66, 67-160 and 160-248) were involved in binding to hTAF(II)68 (NTD). hTAF(II)68-TEC-dependent transcription was enhanced by GAPDH, but not by a GAPDH mutant defective in hTAF(II)68-TEC binding. Moreover, a fusion of GAPDH with the GAL4 DNA-binding domain increased the promoter activity of a reporter containing GAL4 DNA-binding sites, demonstrating the presence of a transactivation domain(s) in GAPDH. The results of the present study suggest that the transactivation potential of the hTAF(II)68-TEC oncogene product is positively modulated by GAPDH.
  • |Base Sequence[MESH]
  • |DNA Primers[MESH]
  • |Electrophoresis, Polyacrylamide Gel[MESH]
  • |Glyceraldehyde-3-Phosphate Dehydrogenases/*metabolism[MESH]
  • |Humans[MESH]
  • |Protein Binding[MESH]
  • |Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization[MESH]
  • |Subcellular Fractions/enzymology[MESH]
  • |TATA-Binding Protein Associated Factors/*physiology[MESH]


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