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10.1097/01.pcc.0000256620.55512.5f http://scihub22266oqcxt.onion/10.1097/01.pcc.0000256620.55512.5f 17251875!ä!17251875 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Crit+Care+Med 2007 ; 8 (1): 1-9 Nephropedia Template TP {{tp|p=17251875|t=2007. Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injury |pdf=|usr=}}{{17251875}} gab.com Text Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injury JO: Pediatr Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=17251875 #FOAvip OBJECTIVE: Magnesium sulfate is neuroprotective in preclinical models, but there are limited safety data regarding its clinical use for pediatric traumatic brain injury. We conducted a pilot study in children with severe traumatic brain injury to a) examine if magnesium sulfate decreases mean arterial pressure, decreases cerebral perfusion pressure, increases intracranial pressure, or adversely effects cardiac conduction; and b) determine the feasibility of a multiple-center trial of magnesium sulfate. DESIGN: Double-blinded, placebo-controlled, randomized pilot trial with repeated measurement of hemodynamic variables. SETTING: Two pediatric trauma centers. PATIENTS: Six children (3 months to 18 yrs) with severe traumatic brain injury. INTERVENTIONS: : Magnesium sulfate (50 mg/kg) bolus followed by (8.3 mg/kg/hr) infusion for 24 hr vs. equivolume placebo. MEASUREMENTS AND MAIN RESULTS: We screened 96 patients with severe traumatic brain injury during 24 months; 20 were eligible for enrollment, six provided informed consent, four received magnesium sulfate, and two received placebo. Before and after study drug infusion, we repeatedly measured blood ionized magnesium concentration, mean arterial pressure, cerebral perfusion pressure, intracranial pressure, heart rate, and corrected QT interval. Mean age (7.9 yrs), mean highest Glasgow Coma Scale score (6), gender (33% boys), inflicted injury rate (17%), and case mortality rate (17%) did not differ between those enrolled and those not enrolled. Compared with baseline, magnesium sulfate did not change cerebral perfusion pressure, intracranial pressure, heart rate, or corrected QT interval. Mean arterial pressure was unchanged until the late phase of magnesium sulfate infusion, when mean arterial pressure rose (82 +/- 5 vs. 93 +/- 6 mm Hg, p < .05). Sixty-four percent of corrected QT interval determinations obtained in the first 6 days after injury exceeded 440 msecs; 12% were >600 msecs. CONCLUSIONS: In children with severe traumatic brain injury, magnesium sulfate administration did not decrease mean arterial pressure or cerebral perfusion pressure or adversely effect cardiac conduction. Our data suggest that enrollment of brain-injured children in a therapeutic trial remains challenging. These results provide information important for clinical trials of magnesium sulfate in children with severe traumatic brain injury. Twit Text FOAVip Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injury ????Pediatr Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=17251875 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17251875 #FOAvip English Wikipedia <ref>{{Cite pmid|17251875}}</ref> Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injury #MMPMID17251875 Natale JE; Guerguerian AM; Joseph JG; McCarter R; Shao C; Slomine B; Christensen J; Johnston MV; Shaffner DH Pediatr Crit Care Med 2007[Jan]; 8 (1): 1-9 PMID17251875show ga OBJECTIVE: Magnesium sulfate is neuroprotective in preclinical models, but there are limited safety data regarding its clinical use for pediatric traumatic brain injury. We conducted a pilot study in children with severe traumatic brain injury to a) examine if magnesium sulfate decreases mean arterial pressure, decreases cerebral perfusion pressure, increases intracranial pressure, or adversely effects cardiac conduction; and b) determine the feasibility of a multiple-center trial of magnesium sulfate. DESIGN: Double-blinded, placebo-controlled, randomized pilot trial with repeated measurement of hemodynamic variables. SETTING: Two pediatric trauma centers. PATIENTS: Six children (3 months to 18 yrs) with severe traumatic brain injury. INTERVENTIONS: : Magnesium sulfate (50 mg/kg) bolus followed by (8.3 mg/kg/hr) infusion for 24 hr vs. equivolume placebo. MEASUREMENTS AND MAIN RESULTS: We screened 96 patients with severe traumatic brain injury during 24 months; 20 were eligible for enrollment, six provided informed consent, four received magnesium sulfate, and two received placebo. Before and after study drug infusion, we repeatedly measured blood ionized magnesium concentration, mean arterial pressure, cerebral perfusion pressure, intracranial pressure, heart rate, and corrected QT interval. Mean age (7.9 yrs), mean highest Glasgow Coma Scale score (6), gender (33% boys), inflicted injury rate (17%), and case mortality rate (17%) did not differ between those enrolled and those not enrolled. Compared with baseline, magnesium sulfate did not change cerebral perfusion pressure, intracranial pressure, heart rate, or corrected QT interval. Mean arterial pressure was unchanged until the late phase of magnesium sulfate infusion, when mean arterial pressure rose (82 +/- 5 vs. 93 +/- 6 mm Hg, p < .05). Sixty-four percent of corrected QT interval determinations obtained in the first 6 days after injury exceeded 440 msecs; 12% were >600 msecs. CONCLUSIONS: In children with severe traumatic brain injury, magnesium sulfate administration did not decrease mean arterial pressure or cerebral perfusion pressure or adversely effect cardiac conduction. Our data suggest that enrollment of brain-injured children in a therapeutic trial remains challenging. These results provide information important for clinical trials of magnesium sulfate in children with severe traumatic brain injury. |Adolescent[MESH] |Blood Pressure/drug effects[MESH] |Brain Injuries/*drug therapy/physiopathology[MESH] |Cerebrovascular Circulation/drug effects[MESH] |Child[MESH] |Child, Preschool[MESH] |Data Interpretation, Statistical[MESH] |Double-Blind Method[MESH] |Electrocardiography[MESH] |Feasibility Studies[MESH] |Female[MESH] |Heart Conduction System/drug effects[MESH] |Humans[MESH] |Infusions, Intravenous[MESH] |Intracranial Pressure/drug effects[MESH] |Magnesium Sulfate/administration & dosage/pharmacology/*therapeutic use[MESH] |Male[MESH] |Neuroprotective Agents/administration & dosage/pharmacology/*therapeutic use[MESH] |Patient Selection[MESH] |Pilot Projects[MESH] |Placebos[MESH] |Safety[MESH]Pilot study to determine the hemodynamic safety and feasibility of mag(epmc).pdf DeepDyve Pubget Overpricing