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10.1111/j.1600-0854.2006.00516.x http://scihub22266oqcxt.onion/10.1111/j.1600-0854.2006.00516.x 17241444!ä!17241444 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Traffic 2007 ; 8 (2): 97-109 Nephropedia Template TP {{tp|p=17241444|t=2007. Sensory cilia and integration of signal transduction in human health and disease |pdf=|usr=}}{{17241444}} gab.com Text Sensory cilia and integration of signal transduction in human health and disease JO: Traffic http://www.kidney.de/pget.php?&tw=1&pmid=17241444 #FOAvip The primary cilium is a hallmark of mammalian tissue cells. Recent research has shown that these organelles display unique sets of selected signal transduction modules including receptors, ion channels, effector proteins and transcription factors that relay chemical and physical stimuli from the extracellular environment in order to control basic cellular processes during embryonic and postnatal development, as well as in tissue homeostasis in adulthood. Consequently, defects in building of the cilium or in transport or function of ciliary signal proteins are associated with a series of pathologies, including developmental disorders and cancer. In this review, we highlight recent examples of the mechanisms by which signal components are selectively targeted and transported to the ciliary membrane and we present an overview of the signal transduction pathways associated with primary and motile cilia in vertebrate cells, including platelet-derived growth factor receptor-alpha (PDGFRalpha), hedgehog and Wnt signaling pathways. Finally, we discuss the functions of these cilia-associated signal transduction pathways and their role in human health and development. Twit Text FOAVip Sensory cilia and integration of signal transduction in human health and disease ????Traffic http://www.kidney.de/pget.php?&tw=1&pmid=17241444 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17241444 #FOAvip English Wikipedia <ref>{{Cite pmid|17241444}}</ref> Sensory cilia and integration of signal transduction in human health and disease #MMPMID17241444 Christensen ST; Pedersen LB; Schneider L; Satir P Traffic 2007[Feb]; 8 (2): 97-109 PMID17241444show ga The primary cilium is a hallmark of mammalian tissue cells. Recent research has shown that these organelles display unique sets of selected signal transduction modules including receptors, ion channels, effector proteins and transcription factors that relay chemical and physical stimuli from the extracellular environment in order to control basic cellular processes during embryonic and postnatal development, as well as in tissue homeostasis in adulthood. Consequently, defects in building of the cilium or in transport or function of ciliary signal proteins are associated with a series of pathologies, including developmental disorders and cancer. In this review, we highlight recent examples of the mechanisms by which signal components are selectively targeted and transported to the ciliary membrane and we present an overview of the signal transduction pathways associated with primary and motile cilia in vertebrate cells, including platelet-derived growth factor receptor-alpha (PDGFRalpha), hedgehog and Wnt signaling pathways. Finally, we discuss the functions of these cilia-associated signal transduction pathways and their role in human health and development. |*Disease[MESH] |*Health[MESH] |*Signal Transduction[MESH] |Animals[MESH] |Cilia/*metabolism[MESH] |Hedgehog Proteins/metabolism[MESH] |Humans[MESH] |Membrane Proteins/*metabolism[MESH] |Protein Transport[MESH] |Receptor, Platelet-Derived Growth Factor alpha/metabolism[MESH]Sensory cilia and integration of signal transduction in human health a(epmc).pdf DeepDyve Pubget Overpricing