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10.1098/rsbl.2004.0253 http://scihub22266oqcxt.onion/10.1098/rsbl.2004.0253 17148142/?report=reader!1626216!17148142     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=17148142&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538       Biol+Lett 2005 ; 1 (2): 113-7 Nephropedia Template TP {{tp|p=17148142|t=2005. Genome gating ; polarized intranuclear trafficking of influenza virus RNPs |pdf=|usr=}}{{17148142}} gab.com Text Genome gating ; polarized intranuclear trafficking of influenza virus RNPs JO: Biol Lett http://www.kidney.de/pget.php?&tw=1&pmid=17148142 #FOAvip Many viruses exploit cellular polarity to constrain the assembly and release of progeny virions to a desired surface. Influenza virus particles are released only from the apical surface of epithelial cells and this polarization is partly owing to specific targeting of the viral membrane proteins to the apical plasma membrane. The RNA genome of the virus is transcribed and replicated in the nucleus, necessitating nuclear export of the individual ribonucleoprotein (RNP) segments before they can be incorporated into budding virus particles. We show that the process of polarized virus assembly begins in the nucleus with the RNPs adopting a novel asymmetric distribution at the inner nuclear membrane prior to their export to the cytoplasm. The viral nucleoprotein, the major protein component of RNPs, displays the same polarized intranuclear distribution in the absence of other influenza virus components, suggesting the existence of a hitherto unrecognized polarity within the mammalian cell nucleus. Twit Text FOAVip Genome gating ; polarized intranuclear trafficking of influenza virus RNPs ????Biol Lett http://www.kidney.de/pget.php?&tw=1&pmid=17148142 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17148142 #FOAvip English Wikipedia <ref>{{Cite pmid|17148142}}</ref> Genome gating ; polarized intranuclear trafficking of influenza virus RNPs #MMPMID17148142 Elton D; Amorim MJ; Medcalf L; Digard P Biol Lett 2005[Jun]; 1 (2): 113-7 PMID17148142show ga Many viruses exploit cellular polarity to constrain the assembly and release of progeny virions to a desired surface. Influenza virus particles are released only from the apical surface of epithelial cells and this polarization is partly owing to specific targeting of the viral membrane proteins to the apical plasma membrane. The RNA genome of the virus is transcribed and replicated in the nucleus, necessitating nuclear export of the individual ribonucleoprotein (RNP) segments before they can be incorporated into budding virus particles. We show that the process of polarized virus assembly begins in the nucleus with the RNPs adopting a novel asymmetric distribution at the inner nuclear membrane prior to their export to the cytoplasm. The viral nucleoprotein, the major protein component of RNPs, displays the same polarized intranuclear distribution in the absence of other influenza virus components, suggesting the existence of a hitherto unrecognized polarity within the mammalian cell nucleus. |Animals[MESH] |Cell Line[MESH] |Cell Polarity[MESH] |Cricetinae[MESH] |Epithelial Cells/virology[MESH] |Genome, Viral[MESH] |Humans[MESH] |Influenza A virus/*physiology[MESH] |Nuclear Envelope/*virology[MESH] |Ribonucleoproteins/*metabolism[MESH] |Viral Proteins/*metabolism[MESH] Genome gating ; polarized intranuclear trafficking of influenza virus(epmc).pdf DeepDyve Pubget Overpricing