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10.1038/nrm2061

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17139332!2953463!17139332
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suck abstract from ncbi

pmid17139332      Nat+Rev+Mol+Cell+Biol 2006 ; 7 (12): 919-31
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  • Editor meets silencer: crosstalk between RNA editing and RNA interference #MMPMID17139332
  • Nishikura K
  • Nat Rev Mol Cell Biol 2006[Dec]; 7 (12): 919-31 PMID17139332show ga
  • The most prevalent type of RNA editing is mediated by ADAR (adenosine deaminase acting on RNA) enzymes, which convert adenosines to inosines (a process known as A-->I RNA editing) in double-stranded (ds)RNA substrates. A-->I RNA editing was long thought to affect only selected transcripts by altering the proteins they encode. However, genome-wide screening has revealed numerous editing sites within inverted Alu repeats in introns and untranslated regions. Also, recent evidence indicates that A-->I RNA editing crosstalks with RNA-interference pathways, which, like A-->I RNA editing, involve dsRNAs. A-->I RNA editing therefore seems to have additional functions, including the regulation of retrotransposons and gene silencing, which adds a new urgency to the challenges of fully understanding ADAR functions.
  • |*RNA Editing[MESH]
  • |*RNA Interference[MESH]
  • |Adenosine Deaminase/chemistry/genetics/*metabolism[MESH]
  • |Adenosine/chemistry/metabolism[MESH]
  • |Alu Elements[MESH]
  • |Animals[MESH]
  • |Gene Expression Regulation[MESH]
  • |Humans[MESH]
  • |Inosine/chemistry/metabolism[MESH]
  • |Introns[MESH]
  • |RNA, Double-Stranded/metabolism[MESH]
  • |RNA, Small Interfering/metabolism[MESH]
  • |RNA-Binding Proteins[MESH]


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