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10.1016/j.neuron.2006.09.033 http://scihub22266oqcxt.onion/10.1016/j.neuron.2006.09.033 17088214!ä!17088214 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuron 2006 ; 52 (3): 485-96 Nephropedia Template TP {{tp|p=17088214|t=2006. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release |pdf=|usr=}}{{17088214}} gab.com Text The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=17088214 #FOAvip A longstanding hypothesis is that ion channels are present in the membranes of synaptic vesicles and might affect neurotransmitter release. Here we demonstrate that TRPM7, a member of the transient receptor potential (TRP) ion channel family, resides in the membrane of synaptic vesicles of sympathetic neurons, forms molecular complexes with the synaptic vesicle proteins synapsin I and synaptotagmin I, and directly interacts with synaptic vesicular snapin. In sympathetic neurons, changes in TRPM7 levels and channel activity alter acetylcholine release, as measured by EPSP amplitudes and decay times in postsynaptic neurons. TRPM7 affects EPSP quantal size, an intrinsic property of synaptic vesicle release. Targeted peptide interference of TRPM7's interaction with snapin affects the amplitudes and kinetics of postsynaptic EPSPs. Thus, vesicular TRPM7 channel activity is critical to neurotransmitter release in sympathetic neurons. Twit Text FOAVip The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=17088214 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17088214 #FOAvip English Wikipedia <ref>{{Cite pmid|17088214}}</ref> The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release #MMPMID17088214 Krapivinsky G; Mochida S; Krapivinsky L; Cibulsky SM; Clapham DE Neuron 2006[Nov]; 52 (3): 485-96 PMID17088214show ga A longstanding hypothesis is that ion channels are present in the membranes of synaptic vesicles and might affect neurotransmitter release. Here we demonstrate that TRPM7, a member of the transient receptor potential (TRP) ion channel family, resides in the membrane of synaptic vesicles of sympathetic neurons, forms molecular complexes with the synaptic vesicle proteins synapsin I and synaptotagmin I, and directly interacts with synaptic vesicular snapin. In sympathetic neurons, changes in TRPM7 levels and channel activity alter acetylcholine release, as measured by EPSP amplitudes and decay times in postsynaptic neurons. TRPM7 affects EPSP quantal size, an intrinsic property of synaptic vesicle release. Targeted peptide interference of TRPM7's interaction with snapin affects the amplitudes and kinetics of postsynaptic EPSPs. Thus, vesicular TRPM7 channel activity is critical to neurotransmitter release in sympathetic neurons. |Acetylcholine/*metabolism[MESH] |Animals[MESH] |Animals, Newborn[MESH] |Blotting, Western/methods[MESH] |Cells, Cultured[MESH] |Cricetinae[MESH] |Cricetulus[MESH] |Electric Stimulation/methods[MESH] |Excitatory Postsynaptic Potentials/drug effects/physiology/radiation effects[MESH] |Green Fluorescent Proteins/metabolism[MESH] |Humans[MESH] |Microscopy, Immunoelectron/methods[MESH] |Mutagenesis/physiology[MESH] |Nerve Tissue Proteins/metabolism[MESH] |Neurons/*physiology/ultrastructure[MESH] |Patch-Clamp Techniques/methods[MESH] |RNA, Small Interfering/pharmacology[MESH] |Rats[MESH] |Rats, Wistar[MESH] |Superior Cervical Ganglion/cytology[MESH] |Synapses/classification/*metabolism[MESH] |Synaptic Transmission/*physiology[MESH] |Synaptic Vesicles/*physiology/ultrastructure[MESH] |TRPM Cation Channels/chemistry/*physiology[MESH] |Transfection/methods[MESH]The TRPM7 ion channel functions in cholinergic synaptic vesicles and a(epmc).pdf DeepDyve Pubget Overpricing