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10.1002/dvdy.20982 http://scihub22266oqcxt.onion/10.1002/dvdy.20982 17072878!ä!17072878 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Dyn 2006 ; 235 (12): 3413-22 Nephropedia Template TP {{tp|p=17072878|t=2006. VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium |pdf=|usr=}}{{17072878}} gab.com Text VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium JO: Dev Dyn http://www.kidney.de/pget.php?&tw=1&pmid=17072878 #FOAvip To introduce temporal control in genetic experiments targeting the endothelium, we established a mouse line expressing tamoxifen-inducible Cre-recombinase (Cre-ERT2) under the regulation of the vascular endothelial cadherin promoter (VECad). Specificity and efficiency of Cre activity was documented by crossing VECad-Cre-ERT2 with the ROSA26R reporter mouse, in which a floxed-stop cassette has been placed upstream of the beta-galactosidase gene. We found that tamoxifen specifically induced widespread recombination in the endothelium of embryonic, neonatal, and adult tissues. Recombination was also documented in tumor-associated vascular beds and in postnatal angiogenesis assays. Furthermore, injection of tamoxifen in adult animals resulted in negligible excision (lower than 0.4%) in the hematopoietic lineage. The VECad-Cre-ERT2 mouse is likely to be a valuable tool to study the function of genes involved in vascular development, homeostasis, and in complex processes involving neoangiogenesis, such as tumor growth. Twit Text FOAVip VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium ????Dev Dyn http://www.kidney.de/pget.php?&tw=1&pmid=17072878 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17072878 #FOAvip English Wikipedia <ref>{{Cite pmid|17072878}}</ref> VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium #MMPMID17072878 Monvoisin A; Alva JA; Hofmann JJ; Zovein AC; Lane TF; Iruela-Arispe ML Dev Dyn 2006[Dec]; 235 (12): 3413-22 PMID17072878show ga To introduce temporal control in genetic experiments targeting the endothelium, we established a mouse line expressing tamoxifen-inducible Cre-recombinase (Cre-ERT2) under the regulation of the vascular endothelial cadherin promoter (VECad). Specificity and efficiency of Cre activity was documented by crossing VECad-Cre-ERT2 with the ROSA26R reporter mouse, in which a floxed-stop cassette has been placed upstream of the beta-galactosidase gene. We found that tamoxifen specifically induced widespread recombination in the endothelium of embryonic, neonatal, and adult tissues. Recombination was also documented in tumor-associated vascular beds and in postnatal angiogenesis assays. Furthermore, injection of tamoxifen in adult animals resulted in negligible excision (lower than 0.4%) in the hematopoietic lineage. The VECad-Cre-ERT2 mouse is likely to be a valuable tool to study the function of genes involved in vascular development, homeostasis, and in complex processes involving neoangiogenesis, such as tumor growth. |Animals[MESH] |Animals, Newborn[MESH] |Antigens, CD/*genetics[MESH] |Cadherins/*genetics[MESH] |Endothelium, Vascular/embryology/growth & development/*metabolism[MESH] |Female[MESH] |Genes, Reporter[MESH] |Integrases/*genetics[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Transgenic[MESH] |Models, Genetic[MESH] |Pregnancy[MESH] |Recombination, Genetic/drug effects[MESH]VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombinat(epmc).pdf DeepDyve Pubget Overpricing