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10.1182/blood-2006-06-031856 http://scihub22266oqcxt.onion/10.1182/blood-2006-06-031856 17023580!1794048!17023580     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=17023580&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Blood 2007 ; 109 (4): 1568-73 Nephropedia Template TP {{tp|p=17023580|t=2007. L-arginine availability regulates T-lymphocyte cell-cycle progression |pdf=|usr=}}{{17023580}} gab.com Text L-arginine availability regulates T-lymphocyte cell-cycle progression JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=17023580 #FOAvip L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion by myeloid-derived suppressor cells producing arginase I is seen in patients with cancer inducing T-cell anergy. We studied how L-Arg starvation could regulate T-cell-cycle progression. Stimulated T cells cultured in the absence of L-Arg are arrested in the G0-G1phase of the cell cycle. This was associated with an inability of T cells to up-regulate cyclin D3 and cyclin-dependent kinase 4 (cdk4), but not cdk6, resulting in an impaired downstream signaling with a decreased phosphorylation of Rb protein and a low expression and binding of E2F1. Silencing of cyclin D3 reproduced the cell cycle arrest caused by L-Arg starvation. The regulation of cyclin D3 and cdk4 by L-Arg starvation occurs at transcriptional and posttranscriptional levels. Signaling through GCN2 kinase is triggered during amino acid starvation. Experiments demonstrated that T cells from GCN2 knock-out mice did not show a decreased proliferation and were able to up-regulate cyclin D3 when cultured in the absence of L-Arg. These results contribute to the understanding of a central mechanism by which cancer and other diseases characterized by high arginase I production may cause T-cell dysfunction. Twit Text FOAVip L-arginine availability regulates T-lymphocyte cell-cycle progression ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=17023580 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17023580 #FOAvip English Wikipedia <ref>{{Cite pmid|17023580}}</ref> L-arginine availability regulates T-lymphocyte cell-cycle progression #MMPMID17023580 Rodriguez PC; Quiceno DG; Ochoa AC Blood 2007[Feb]; 109 (4): 1568-73 PMID17023580show ga L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion by myeloid-derived suppressor cells producing arginase I is seen in patients with cancer inducing T-cell anergy. We studied how L-Arg starvation could regulate T-cell-cycle progression. Stimulated T cells cultured in the absence of L-Arg are arrested in the G0-G1phase of the cell cycle. This was associated with an inability of T cells to up-regulate cyclin D3 and cyclin-dependent kinase 4 (cdk4), but not cdk6, resulting in an impaired downstream signaling with a decreased phosphorylation of Rb protein and a low expression and binding of E2F1. Silencing of cyclin D3 reproduced the cell cycle arrest caused by L-Arg starvation. The regulation of cyclin D3 and cdk4 by L-Arg starvation occurs at transcriptional and posttranscriptional levels. Signaling through GCN2 kinase is triggered during amino acid starvation. Experiments demonstrated that T cells from GCN2 knock-out mice did not show a decreased proliferation and were able to up-regulate cyclin D3 when cultured in the absence of L-Arg. These results contribute to the understanding of a central mechanism by which cancer and other diseases characterized by high arginase I production may cause T-cell dysfunction. |*Cell Cycle[MESH] |*Clonal Anergy[MESH] |Animals[MESH] |Arginine/analysis/deficiency/*physiology[MESH] |Cell Proliferation[MESH] |Cyclin D3[MESH] |Cyclin-Dependent Kinases/genetics[MESH] |Cyclins/genetics[MESH] |Gene Expression Regulation[MESH] |Humans[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Neoplasms/immunology[MESH] |Protein Serine-Threonine Kinases[MESH]L-arginine availability regulates T-lymphocyte cell-cycle progression (epmc).pdf DeepDyve Pubget Overpricing