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10.1002/jmv.20708 http://scihub22266oqcxt.onion/10.1002/jmv.20708 16998895!ä!16998895 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2006 ; 78 (11): 1374-84 Nephropedia Template TP {{tp|p=16998895|t=2006. Genetic drift of parvovirus B19 is found in AIDS patients with persistent B19 infection |pdf=|usr=}}{{16998895}} gab.com Text Genetic drift of parvovirus B19 is found in AIDS patients with persistent B19 infection JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=16998895 #FOAvip It is generally thought that parvovirus B19 is stable genetically. Consistently, genetic drift has not been found in patients with persistent B19 infection. In this report, longitudinal genetic changes in NS1 and VP1 gene of B19 isolates from three AIDS patients with persistent B19 infection were studied. One of the three patients was not treated with highly active anti-retroviral therapy (HAART). B19 viral DNA from these patients was amplified by polymerase chain reaction (PCR) and then sequenced directly. A single genetic change was found in the B19 isolate obtained from the patient not treated with HAART on Day 10 after intravenous immunoglobulin (IVIG) treatment. The nucleotide sequences of B19 isolated from this patient, then remained unchanged over a period of 11 months. Analysis of NS1 clones derived from his longitudinal viral isolates showed the existence of quasi-species but genetic drift was not found. One of the other two patients treated with HAART experienced treatment failure; he was later treated with mega-HAART. In contrast to the genetic stability of B19 isolates from the patient not treated with HAART, multiple genetic changes were discovered in the viral isolates from the two other patients after HAART and mega-HAART, respectively. Through analysis of B19 clones, the frequency of clones containing these mutations confirmed the genetic drift. Nucleotide substitutions seen in VP2 gene of isolates with genetic drift from both patients were all non-conserved, suggesting that they are positively selected. Twit Text FOAVip Genetic drift of parvovirus B19 is found in AIDS patients with persistent B19 infection ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=16998895 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16998895 #FOAvip English Wikipedia <ref>{{Cite pmid|16998895}}</ref> Genetic drift of parvovirus B19 is found in AIDS patients with persistent B19 infection #MMPMID16998895 Hung CC; Sheng WH; Lee KL; Yang SJ; Chen MY J Med Virol 2006[Nov]; 78 (11): 1374-84 PMID16998895show ga It is generally thought that parvovirus B19 is stable genetically. Consistently, genetic drift has not been found in patients with persistent B19 infection. In this report, longitudinal genetic changes in NS1 and VP1 gene of B19 isolates from three AIDS patients with persistent B19 infection were studied. One of the three patients was not treated with highly active anti-retroviral therapy (HAART). B19 viral DNA from these patients was amplified by polymerase chain reaction (PCR) and then sequenced directly. A single genetic change was found in the B19 isolate obtained from the patient not treated with HAART on Day 10 after intravenous immunoglobulin (IVIG) treatment. The nucleotide sequences of B19 isolated from this patient, then remained unchanged over a period of 11 months. Analysis of NS1 clones derived from his longitudinal viral isolates showed the existence of quasi-species but genetic drift was not found. One of the other two patients treated with HAART experienced treatment failure; he was later treated with mega-HAART. In contrast to the genetic stability of B19 isolates from the patient not treated with HAART, multiple genetic changes were discovered in the viral isolates from the two other patients after HAART and mega-HAART, respectively. Through analysis of B19 clones, the frequency of clones containing these mutations confirmed the genetic drift. Nucleotide substitutions seen in VP2 gene of isolates with genetic drift from both patients were all non-conserved, suggesting that they are positively selected. |*Genetic Drift[MESH] |AIDS-Related Opportunistic Infections/virology[MESH] |Acquired Immunodeficiency Syndrome/*complications[MESH] |Humans[MESH] |Male[MESH] |Parvoviridae Infections/*complications/*virology[MESH] |Parvovirus B19, Human/*genetics/isolation & purification[MESH]Genetic drift of parvovirus B19 is found in AIDS patients with persist(epmc).pdf DeepDyve Pubget Overpricing