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10.1016/j.bbr.2006.08.023 http://scihub22266oqcxt.onion/10.1016/j.bbr.2006.08.023 16997392/?report=reader!3709864!16997392     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Behav+Brain+Res 2007 ; 176 (1): 66-74 Nephropedia Template TP {{tp|p=16997392|t=2007. Animal models of restricted repetitive behavior in autism |pdf=|usr=}}{{16997392}} gab.com Text Animal models of restricted repetitive behavior in autism JO: Behav Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=16997392 #FOAvip Restricted, repetitive behavior, along with deficits in social reciprocity and communication, is diagnostic of autism. Animal models relevant to this domain generally fall into three classes: repetitive behavior associated with targeted insults to the CNS; repetitive behavior induced by pharmacological agents; and repetitive behavior associated with restricted environments and experience. The extant literature provides potential models of the repetitive behavioral phenotype in autism rather than attempts to model the etiology or pathophysiology of restricted, repetitive behavior, as these are poorly understood. This review focuses on our work with deer mice which exhibit repetitive behaviors associated with environmental restriction. Repetitive behaviors are the most common category of abnormal behavior observed in confined animals and larger, more complex environments substantially reduce the development and expression of such behavior. Studies with this model, including environmental enrichment effects, suggest alterations in cortical-basal ganglia circuitry in the development and expression of repetitive behavior. Considerably more work needs to be done in this area, particularly in modeling the development of aberrant repetitive behavior. As mutant mouse models continue to proliferate, there should be a number of promising genetic models to pursue. Twit Text FOAVip Animal models of restricted repetitive behavior in autism ????Behav Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=16997392 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16997392 #FOAvip English Wikipedia <ref>{{Cite pmid|16997392}}</ref> Animal models of restricted repetitive behavior in autism #MMPMID16997392 Lewis MH; Tanimura Y; Lee LW; Bodfish JW Behav Brain Res 2007[Jan]; 176 (1): 66-74 PMID16997392show ga Restricted, repetitive behavior, along with deficits in social reciprocity and communication, is diagnostic of autism. Animal models relevant to this domain generally fall into three classes: repetitive behavior associated with targeted insults to the CNS; repetitive behavior induced by pharmacological agents; and repetitive behavior associated with restricted environments and experience. The extant literature provides potential models of the repetitive behavioral phenotype in autism rather than attempts to model the etiology or pathophysiology of restricted, repetitive behavior, as these are poorly understood. This review focuses on our work with deer mice which exhibit repetitive behaviors associated with environmental restriction. Repetitive behaviors are the most common category of abnormal behavior observed in confined animals and larger, more complex environments substantially reduce the development and expression of such behavior. Studies with this model, including environmental enrichment effects, suggest alterations in cortical-basal ganglia circuitry in the development and expression of repetitive behavior. Considerably more work needs to be done in this area, particularly in modeling the development of aberrant repetitive behavior. As mutant mouse models continue to proliferate, there should be a number of promising genetic models to pursue. |*Behavior, Animal[MESH] |*Environment[MESH] |*Stereotyped Behavior[MESH] |Animals[MESH] |Autistic Disorder/metabolism/pathology/*physiopathology[MESH] |Basal Ganglia/metabolism/pathology[MESH] |Dendrites/metabolism/pathology[MESH] |Disease Models, Animal[MESH] |Housing, Animal[MESH] |Neurons/metabolism/pathology[MESH] |Peromyscus[MESH] |Phenotype[MESH]Animal models of restricted repetitive behavior in autism (epmc).pdf DeepDyve Pubget Overpricing