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10.1002/eji.200535587 http://scihub22266oqcxt.onion/10.1002/eji.200535587 16955520!7163486!16955520     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2006 ; 36 (10): 2649-57 Nephropedia Template TP {{tp|p=16955520|t=2006. Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions |pdf=|usr=}}{{16955520}} gab.com Text Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=16955520 #FOAvip Reactive nitrogen intermediates (RNI), like nitric oxide (NO) and peroxynitrite, have antiviral effects against certain viruses. Hantaviruses, like other members of the Bunyaviridae family, have previously not been shown to be sensitive to RNI. In this study, we compared the effects of NO and peroxynitrite on hantavirus replication and free mature virions in vitro, and of inducible nitric oxide synthase (iNOS) in hantavirus-infected suckling mice. The NO-generating compound S-nitroso-N-acetylpenicillamine (SNAP), as well as cytokine-induced NO, strongly inhibited hantavirus replication in Vero E6 cells, while pretreatment of free virions with SNAP only had a limited effect on their viability. In contrast, 3-morpholinosydnonimine hydrochloride (SIN-1), a peroxynitrite donor, inhibited virus replication only to a very low extent in vitro, but pretreatment of virus with SIN-1 led to a considerably lowered viability of the virions. Infections of various human cell types per se did not induce NO production. The viral titers in iNOS(-/-) mice were higher compared to the controls, suggesting that NO inhibits hantavirus replication in vivo. In conclusion, we show that NO has strong antiviral effects on hantavirus replication, and peryoxynitrite on mature free virions, suggesting that different RNI can have different effects on various parts of the replication cycle for the same virus. Twit Text FOAVip Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=16955520 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16955520 #FOAvip English Wikipedia <ref>{{Cite pmid|16955520}}</ref> Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions #MMPMID16955520 Klingstrom J; Akerstrom S; Hardestam J; Stoltz M; Simon M; Falk KI; Mirazimi A; Rottenberg M; Lundkvist A Eur J Immunol 2006[Oct]; 36 (10): 2649-57 PMID16955520show ga Reactive nitrogen intermediates (RNI), like nitric oxide (NO) and peroxynitrite, have antiviral effects against certain viruses. Hantaviruses, like other members of the Bunyaviridae family, have previously not been shown to be sensitive to RNI. In this study, we compared the effects of NO and peroxynitrite on hantavirus replication and free mature virions in vitro, and of inducible nitric oxide synthase (iNOS) in hantavirus-infected suckling mice. The NO-generating compound S-nitroso-N-acetylpenicillamine (SNAP), as well as cytokine-induced NO, strongly inhibited hantavirus replication in Vero E6 cells, while pretreatment of free virions with SNAP only had a limited effect on their viability. In contrast, 3-morpholinosydnonimine hydrochloride (SIN-1), a peroxynitrite donor, inhibited virus replication only to a very low extent in vitro, but pretreatment of virus with SIN-1 led to a considerably lowered viability of the virions. Infections of various human cell types per se did not induce NO production. The viral titers in iNOS(-/-) mice were higher compared to the controls, suggesting that NO inhibits hantavirus replication in vivo. In conclusion, we show that NO has strong antiviral effects on hantavirus replication, and peryoxynitrite on mature free virions, suggesting that different RNI can have different effects on various parts of the replication cycle for the same virus. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Blotting, Western[MESH] |Brain/virology[MESH] |Cells, Cultured[MESH] |Chlorocebus aethiops[MESH] |Hantavirus Infections/immunology/*metabolism[MESH] |Humans[MESH] |In Vitro Techniques[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Molsidomine/analogs & derivatives/pharmacology[MESH] |Nitric Oxide Donors/pharmacology[MESH] |Nitric Oxide Synthase Type II/metabolism[MESH] |Nitric Oxide/*pharmacology[MESH] |Orthohantavirus/*drug effects/physiology[MESH] |Peroxynitrous Acid/*pharmacology[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |S-Nitroso-N-Acetylpenicillamine/pharmacology[MESH] |Vero Cells[MESH] |Virion/*drug effects[MESH]Nitric oxide and peroxynitrite have different antiviral effects agains(epmc).pdf DeepDyve Pubget Overpricing