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suck abstract from ncbi


10.1086/506361

http://scihub22266oqcxt.onion/10.1086/506361
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16941345!?!16941345

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suck abstract from ncbi

pmid16941345      J+Infect+Dis 2006 ; 194 (6): 790-4
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  • Parvovirus B19 empty capsids as antigen carriers for presentation of antigenic determinants of dengue 2 virus #MMPMID16941345
  • Amexis G; Young NS
  • J Infect Dis 2006[Sep]; 194 (6): 790-4 PMID16941345show ga
  • For the production of dengue-vaccine candidates, empty capsids, or virus-like particles (VLPs), of parvovirus B19 that carry dengue 2-specific epitopes were employed as antigen carriers. Two epitopes (comprising amino acids 352-368 and 386-397) of domain BIII of the envelope glycoprotein were chosen to produce recombinant B19 VLPs for immunization of BALB/c mice. Serum samples from immunized mice revealed that recombinant B19 VLPs elicited strong humoral immune responses. In summary, this B19 VLP-vaccine platform produced high (> or =2.0 x 10(5)) anti-dengue 2 titers and robust (< or =1 120) 50%-plaque-reduction neutralization test (PRNT(50)) titers, which effectively neutralized live dengue 2 virus in PRNT(50) assays.
  • |Animals[MESH]
  • |Antibodies, Viral/blood/metabolism[MESH]
  • |Antigen Presentation/*physiology[MESH]
  • |Capsid Proteins/genetics/*immunology[MESH]
  • |Cell Line[MESH]
  • |Dengue Virus/genetics/*immunology[MESH]
  • |Epitopes/genetics/metabolism[MESH]
  • |Gene Order[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |Neutralization Tests[MESH]
  • |Parvovirus B19, Human/genetics/*immunology[MESH]
  • |Recombinant Proteins/*immunology[MESH]


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