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10.1080/13550280600827351 http://scihub22266oqcxt.onion/10.1080/13550280600827351 16877300!ä!16877300 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurovirol 2006 ; 12 (3): 190-9 Nephropedia Template TP {{tp|p=16877300|t=2006. Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex |pdf=|usr=}}{{16877300}} gab.com Text Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex JO: J Neurovirol http://www.kidney.de/pget.php?&tw=1&pmid=16877300 #FOAvip Although animal parvoviruses have long been recognized as causes of brain pathology in multiple animal models, especially during early development, human parvoviruses are rarely thought of as neurotropic or causes of neuropathology in humans. However, several recent case reports have suggested possible associations of parvovirus B19 (B19) infection with various neurological and neuropsychiatric symptoms. Adeno-associated virus 2 (AAV2) is related to B19 but has thus far not been shown to be associated with any human disease but is of clinical interest because of the recent use of recombinant AAV vectors in human gene therapy, including gene delivery to the brain. To date, there have been no large-scale studies of the propensity of wild-type human parvoviruses to infect the brain. The Stanley Medical Research Institute Brain Collection offered a unique opportunity to study a large sample (n = 104) of dorsolateral prefrontal cortex (DLPC) DNAs isolated from unaffected control, schizophrenic, and bipolar disorder brains for the presence of parvoviral sequences. This is the first investigator-blinded study to document the presence of parvoviral sequences in the DLPC by utilizing highly sensitive nested polymerase chain reaction (nPCR) and DNA sequencing. Of the overall sample, 6.7% to 12.5% were positive for AAV2, and 14.4% to 42.3% were positive for B19 sequences, with no statistical differences among subgroups. This is the first report to demonstrate the presence of human parvoviruses in a large cohort of adult DLPC, which underscores the need to gain a better insight into the basic biology of parvovirus-brain interactions, including mechanisms of infection and persistence. Twit Text FOAVip Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex ????J Neurovirol http://www.kidney.de/pget.php?&tw=1&pmid=16877300 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16877300 #FOAvip English Wikipedia <ref>{{Cite pmid|16877300}}</ref> Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex #MMPMID16877300 Hobbs JA J Neurovirol 2006[Jun]; 12 (3): 190-9 PMID16877300show ga Although animal parvoviruses have long been recognized as causes of brain pathology in multiple animal models, especially during early development, human parvoviruses are rarely thought of as neurotropic or causes of neuropathology in humans. However, several recent case reports have suggested possible associations of parvovirus B19 (B19) infection with various neurological and neuropsychiatric symptoms. Adeno-associated virus 2 (AAV2) is related to B19 but has thus far not been shown to be associated with any human disease but is of clinical interest because of the recent use of recombinant AAV vectors in human gene therapy, including gene delivery to the brain. To date, there have been no large-scale studies of the propensity of wild-type human parvoviruses to infect the brain. The Stanley Medical Research Institute Brain Collection offered a unique opportunity to study a large sample (n = 104) of dorsolateral prefrontal cortex (DLPC) DNAs isolated from unaffected control, schizophrenic, and bipolar disorder brains for the presence of parvoviral sequences. This is the first investigator-blinded study to document the presence of parvoviral sequences in the DLPC by utilizing highly sensitive nested polymerase chain reaction (nPCR) and DNA sequencing. Of the overall sample, 6.7% to 12.5% were positive for AAV2, and 14.4% to 42.3% were positive for B19 sequences, with no statistical differences among subgroups. This is the first report to demonstrate the presence of human parvoviruses in a large cohort of adult DLPC, which underscores the need to gain a better insight into the basic biology of parvovirus-brain interactions, including mechanisms of infection and persistence. |Adult[MESH] |Animals[MESH] |Bipolar Disorder/*virology[MESH] |Cell Line[MESH] |Cohort Studies[MESH] |DNA, Viral/analysis[MESH] |Dependovirus/genetics/*isolation & purification[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Middle Aged[MESH] |Parvoviridae Infections/*complications/diagnosis/virology[MESH] |Parvovirus B19, Human/genetics/*isolation & purification[MESH] |Polymerase Chain Reaction/methods/standards[MESH] |Prefrontal Cortex/*virology[MESH] |Reproducibility of Results[MESH]Detection of adeno-associated virus 2 and parvovirus B19 in the human (epmc).pdf DeepDyve Pubget Overpricing