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10.1016/j.bbr.2006.06.013 http://scihub22266oqcxt.onion/10.1016/j.bbr.2006.06.013 16860408!ä!16860408 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=16860408&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Behav+Brain+Res 2007 ; 176 (1): 141-8 Nephropedia Template TP {{tp|p=16860408|t=2007. Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus |pdf=|usr=}}{{16860408}} gab.com Text Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus JO: Behav Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=16860408 #FOAvip Autism spectrum disorders (ASD) have been the focus of a great deal of research and clinical speculation. This intense interest relates to both the perplexing pathogenesis and devastating consequences of these disorders. One of the obstacles to understanding the pathogenesis of autism and to developing efficient treatment has been the paucity of animal models that could be used for hypotheses-driven mechanistic studies of abnormal brain and behavior development and for the pre-clinical testing novel pharmacological treatments. In this report, we briefly review our animal model of ASD based on neonatal Borna disease virus (BDV) infection and present new data about abnormal social interaction in adult BDV-infected rats. We found that neonatal BDV infection profoundly affected social behaviors in adult rats. Compared to the control rats, both 90- and 180-day-old infected rats spent less time in active social interaction and more time in following their partners. In the intruder-resident test, the BDV-infected resident rats exhibited less aggression towards the intruders and showed more the following-the-intruder behavior. The following-the-partner behavior may be an example of "stereotypic" activity due to BDV-induced abnormal social communication between rats. The previously published results and present findings indicate that neonatal BDV infection significantly altered the normal pattern of social interaction in rats. Co-localization of activated microglia and dying Purkinje cells in BDV-infected rats suggests that the BDV model could be used to study a pathogenic link of Purkinje cell dropout and neuroinflammation to abnormal social behaviors. Twit Text FOAVip Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus ????Behav Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=16860408 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16860408 #FOAvip English Wikipedia <ref>{{Cite pmid|16860408}}</ref> Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus #MMPMID16860408 Lancaster K; Dietz DM; Moran TH; Pletnikov MV Behav Brain Res 2007[Jan]; 176 (1): 141-8 PMID16860408show ga Autism spectrum disorders (ASD) have been the focus of a great deal of research and clinical speculation. This intense interest relates to both the perplexing pathogenesis and devastating consequences of these disorders. One of the obstacles to understanding the pathogenesis of autism and to developing efficient treatment has been the paucity of animal models that could be used for hypotheses-driven mechanistic studies of abnormal brain and behavior development and for the pre-clinical testing novel pharmacological treatments. In this report, we briefly review our animal model of ASD based on neonatal Borna disease virus (BDV) infection and present new data about abnormal social interaction in adult BDV-infected rats. We found that neonatal BDV infection profoundly affected social behaviors in adult rats. Compared to the control rats, both 90- and 180-day-old infected rats spent less time in active social interaction and more time in following their partners. In the intruder-resident test, the BDV-infected resident rats exhibited less aggression towards the intruders and showed more the following-the-intruder behavior. The following-the-partner behavior may be an example of "stereotypic" activity due to BDV-induced abnormal social communication between rats. The previously published results and present findings indicate that neonatal BDV infection significantly altered the normal pattern of social interaction in rats. Co-localization of activated microglia and dying Purkinje cells in BDV-infected rats suggests that the BDV model could be used to study a pathogenic link of Purkinje cell dropout and neuroinflammation to abnormal social behaviors. |*Social Behavior[MESH] |Age Factors[MESH] |Animal Communication[MESH] |Animals[MESH] |Animals, Newborn/virology[MESH] |Autistic Disorder/*physiopathology/virology[MESH] |Borna Disease/*complications/virology[MESH] |Borna disease virus[MESH] |Brain Damage, Chronic/physiopathology/virology[MESH] |Brain/growth & development/*physiopathology/virology[MESH] |Disease Models, Animal[MESH] |Exploratory Behavior[MESH] |Habituation, Psychophysiologic[MESH] |Rats[MESH] |Rats, Inbred Lew[MESH] |Social Behavior Disorders/*physiopathology/virology[MESH]Abnormal social behaviors in young and adult rats neonatally infected (epmc).pdf DeepDyve Pubget Overpricing