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10.1128/JVI.02388-05

http://scihub22266oqcxt.onion/10.1128/JVI.02388-05
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16775358!1488968!16775358
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suck abstract from ncbi

pmid16775358      J+Virol 2006 ; 80 (13): 6697-701
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  • A highly restricted T-cell receptor dominates the CD8+ T-cell response to parvovirus B19 infection in HLA-A*2402-positive individuals #MMPMID16775358
  • Kasprowicz V; Isa A; Jeffery K; Broliden K; Tolfvenstam T; Klenerman P; Bowness P
  • J Virol 2006[Jul]; 80 (13): 6697-701 PMID16775358show ga
  • Six of seven HLA-A*2402-positive individuals with acute parvovirus B19 infections made vigorous CD8-positive cytotoxic T-cell (CTL) responses to the viral epitope FYTPLADQF. All responders showed highly focused T-cell receptor (TCR) usage, using almost exclusively BV5.1. The BV5.1 TCR dominated the acute response, was maintained over time, and was also used by a remotely infected individual. Nine CTL clones and two oligoclonal lines obtained from three unrelated individuals used BV5.1, BJ2.1, and a conserved TCR CDR3 of nine amino acids. This commonly recognized epitope is likely important in long-term protective immunity and should be included in vaccine design.
  • |CD8-Positive T-Lymphocytes/*immunology/virology[MESH]
  • |Complementarity Determining Regions/genetics/*immunology[MESH]
  • |Epitopes, T-Lymphocyte/*immunology[MESH]
  • |Female[MESH]
  • |HLA-A Antigens/genetics/*immunology[MESH]
  • |HLA-A24 Antigen[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Parvoviridae Infections/genetics/*immunology[MESH]
  • |Parvovirus B19, Human/*immunology[MESH]


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