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10.4049/jimmunol.176.8.4530 http://scihub22266oqcxt.onion/10.4049/jimmunol.176.8.4530 16585542!ä!16585542 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2006 ; 176 (8): 4530-3 Nephropedia Template TP {{tp|p=16585542|t=2006. Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus |pdf=|usr=}}{{16585542}} gab.com Text Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=16585542 #FOAvip Hypercytokinemia has been considered to be responsible for hemophagocytosis and multiorgan failure in severe human cases of H5N1 viral infection. In this study, we show a recombinant hemagglutinin (H5) from a H5N1 virus may suppress the perforin expression and reduce cytotoxicity of human CD8+ T cells to kill H5-bearing cells. The persistence of H5-presenting cells provides sustained stimulation and leads to a marked lymphoproliferation and IFN-gamma hyperproduction. We propose the IFN-gamma hyperproduction may explain macrophage overactivation and subsequent hypercytokinemia and hemophagocytosis in severe human cases of avian influenza. Twit Text FOAVip Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=16585542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16585542 #FOAvip English Wikipedia <ref>{{Cite pmid|16585542}}</ref> Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus #MMPMID16585542 Hsieh SM; Chang SC J Immunol 2006[Apr]; 176 (8): 4530-3 PMID16585542show ga Hypercytokinemia has been considered to be responsible for hemophagocytosis and multiorgan failure in severe human cases of H5N1 viral infection. In this study, we show a recombinant hemagglutinin (H5) from a H5N1 virus may suppress the perforin expression and reduce cytotoxicity of human CD8+ T cells to kill H5-bearing cells. The persistence of H5-presenting cells provides sustained stimulation and leads to a marked lymphoproliferation and IFN-gamma hyperproduction. We propose the IFN-gamma hyperproduction may explain macrophage overactivation and subsequent hypercytokinemia and hemophagocytosis in severe human cases of avian influenza. |Adult[MESH] |CD8-Positive T-Lymphocytes/cytology/*immunology[MESH] |Cell Proliferation[MESH] |Cytotoxicity, Immunologic[MESH] |Dendritic Cells/immunology[MESH] |Hemagglutinin Glycoproteins, Influenza Virus/*immunology[MESH] |Humans[MESH] |In Vitro Techniques[MESH] |Influenza A Virus, H5N1 Subtype/*immunology[MESH] |Influenza Vaccines/administration & dosage[MESH] |Interferon-gamma/biosynthesis[MESH] |Kinetics[MESH] |Lymphocyte Activation[MESH] |Membrane Glycoproteins/*biosynthesis[MESH] |Perforin[MESH] |Pore Forming Cytotoxic Proteins[MESH]Insufficient perforin expression in CD8+ T cells in response to hemagg(epmc).pdf DeepDyve Pubget Overpricing