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10.1208/aapsj080109 http://scihub22266oqcxt.onion/10.1208/aapsj080109 16584136/?report=reader!2751425!16584136     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AAPS+J 2006 ; 8 (1): E76-88 Nephropedia Template TP {{tp|p=16584136|t=2006. CNS drug delivery: opioid peptides and the blood-brain barrier |pdf=|usr=}}{{16584136}} gab.com Text CNS drug delivery: opioid peptides and the blood-brain barrier JO: AAPS J http://www.kidney.de/pget.php?&tw=1&pmid=16584136 #FOAvip Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Opioid peptide activity within the central nervous system (CNS) is of particular interest for the treatment of pain owing to the elevated potency of peptides and the centrally mediated actions of pain processes. Despite this potential, peptides have seen limited use as clinically viable drugs for the treatment of pain. Reasons for the limited use are primarily based in the physiochemical and biochemical nature of peptides. Numerous approaches have been devised in an attempt to improve peptide drug delivery to the brain, with variable results. This review describes different approaches to peptide design/modification and provides examples of the value of these strategies to CNS delivery of peptide drugs. The various modes of modification of therapeutic peptides may be amalgamated, creating more efficacious "hybrid" peptides, with synergistic delivery to the CNS. The ongoing development of these strategies provides promise that peptide drugs may be useful for the treatment of pain and other neurologically-based disease states in the future. Twit Text FOAVip CNS drug delivery: opioid peptides and the blood-brain barrier ????AAPS J http://www.kidney.de/pget.php?&tw=1&pmid=16584136 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16584136 #FOAvip English Wikipedia <ref>{{Cite pmid|16584136}}</ref> CNS drug delivery: opioid peptides and the blood-brain barrier #MMPMID16584136 Witt KA; Davis TP AAPS J 2006[Feb]; 8 (1): E76-88 PMID16584136show ga Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Opioid peptide activity within the central nervous system (CNS) is of particular interest for the treatment of pain owing to the elevated potency of peptides and the centrally mediated actions of pain processes. Despite this potential, peptides have seen limited use as clinically viable drugs for the treatment of pain. Reasons for the limited use are primarily based in the physiochemical and biochemical nature of peptides. Numerous approaches have been devised in an attempt to improve peptide drug delivery to the brain, with variable results. This review describes different approaches to peptide design/modification and provides examples of the value of these strategies to CNS delivery of peptide drugs. The various modes of modification of therapeutic peptides may be amalgamated, creating more efficacious "hybrid" peptides, with synergistic delivery to the CNS. The ongoing development of these strategies provides promise that peptide drugs may be useful for the treatment of pain and other neurologically-based disease states in the future. |Animals[MESH] |Blood-Brain Barrier/*drug effects/metabolism[MESH] |Central Nervous System/*drug effects/metabolism[MESH] |Drug Delivery Systems/*methods[MESH] |Humans[MESH]CNS drug delivery: opioid peptides and the blood-brain barrier (epmc).pdf DeepDyve Pubget Overpricing