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10.1086/500954 http://scihub22266oqcxt.onion/10.1086/500954 16518756!7109654!16518756     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect+Dis 2006 ; 193 (7): 945-53 Nephropedia Template TP {{tp|p=16518756|t=2006. Functional tumor necrosis factor-related apoptosis-inducing ligand production by avian influenza virus-infected macrophages |pdf=|usr=}}{{16518756}} gab.com Text Functional tumor necrosis factor-related apoptosis-inducing ligand production by avian influenza virus-infected macrophages JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=16518756 #FOAvip Severe human disease associated with influenza A H5N1 virus was first detected in Hong Kong in 1997. Its recent reemergence in Asia and high associated mortality highlight the need to understand its pathogenesis. We investigated the roles of death receptor ligands (DRLs) in H5N1 infection. Significant up-regulation of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha, but not Fas ligand (FasL) mRNA, was detected in human monocyte-derived macrophages (MDMs) infected with avian influenza viruses A/Hong Kong/483/97 (H5N1/97) or its precursor, A/Quail/Hong Kong/G1/97. H5N1/97-infected MDMs exhibited the strongest induction of apoptosis in Jurkat T cells, and it could be reduced by TRAIL-receptor 2 blocking antibody. Furthermore, influenza virus infection enhanced the sensitivity of Jurkat T cells to apoptosis induced by TNF-alpha, TRAIL, and FasL. Our data suggested that functional TRAIL produced by influenza virus-infected MDMs was related to their cytotoxicity and that the enhanced sensitization to DRL-induced apoptosis detected in avian influenza may contribute to disease pathogenesis. Twit Text FOAVip Functional tumor necrosis factor-related apoptosis-inducing ligand production by avian influenza virus-infected macrophages ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=16518756 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16518756 #FOAvip English Wikipedia <ref>{{Cite pmid|16518756}}</ref> Functional tumor necrosis factor-related apoptosis-inducing ligand production by avian influenza virus-infected macrophages #MMPMID16518756 Zhou J; Law HK; Cheung CY; Ng IH; Peiris JS; Lau YL J Infect Dis 2006[Apr]; 193 (7): 945-53 PMID16518756show ga Severe human disease associated with influenza A H5N1 virus was first detected in Hong Kong in 1997. Its recent reemergence in Asia and high associated mortality highlight the need to understand its pathogenesis. We investigated the roles of death receptor ligands (DRLs) in H5N1 infection. Significant up-regulation of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha, but not Fas ligand (FasL) mRNA, was detected in human monocyte-derived macrophages (MDMs) infected with avian influenza viruses A/Hong Kong/483/97 (H5N1/97) or its precursor, A/Quail/Hong Kong/G1/97. H5N1/97-infected MDMs exhibited the strongest induction of apoptosis in Jurkat T cells, and it could be reduced by TRAIL-receptor 2 blocking antibody. Furthermore, influenza virus infection enhanced the sensitivity of Jurkat T cells to apoptosis induced by TNF-alpha, TRAIL, and FasL. Our data suggested that functional TRAIL produced by influenza virus-infected MDMs was related to their cytotoxicity and that the enhanced sensitization to DRL-induced apoptosis detected in avian influenza may contribute to disease pathogenesis. |*Apoptosis[MESH] |Apoptosis Regulatory Proteins/*biosynthesis/genetics[MESH] |Caspase 3[MESH] |Caspases/analysis[MESH] |Fas Ligand Protein[MESH] |Gene Expression[MESH] |Humans[MESH] |Influenza A Virus, H5N1 Subtype/*pathogenicity[MESH] |Jurkat Cells[MESH] |Macrophages/*virology[MESH] |Membrane Glycoproteins/*biosynthesis/genetics[MESH] |RNA, Messenger/analysis[MESH] |Receptors, TNF-Related Apoptosis-Inducing Ligand[MESH] |Receptors, Tumor Necrosis Factor/antagonists & inhibitors[MESH] |T-Lymphocytes/*cytology[MESH] |TNF-Related Apoptosis-Inducing Ligand[MESH] |Tumor Necrosis Factor-alpha/*biosynthesis/genetics[MESH]Functional tumor necrosis factor-related apoptosis-inducing ligand pro(epmc).pdf DeepDyve Pubget Overpricing