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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Chin+Med 2006 ; 34 (1): 157-69 Nephropedia Template TP
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Macrophage-mediated inhibitory effect of Zingiber officinale Rosc, a traditional oriental herbal medicine, on the growth of influenza A/Aichi/2/68 virus #MMPMID16437748
Imanishi N; Andoh T; Mantani N; Sakai S; Terasawa K; Shimada Y; Sato M; Katada Y; Ueda K; Ochiai H
Am J Chin Med 2006[]; 34 (1): 157-69 PMID16437748show ga
The inhibitory effect of Zingiber officinale Rosc (ZOR), an Oriental traditional herbal medicine, on the growth of influenza A/Aichi/2/68 (Aichi) virus was investigated in Madin-Darby canine kidney (MDCK) cells. Direct addition of ZOR (0.1 approximately 100 microg/ml) to the infected cells did not have any inhibitory effect. However, the ZOR-induced conditioned medium (ZOR-CM) of RAW cells, a murine macrophage (Mphi) cell line, exhibited an apparent inhibitory effect on MDCK cells without cytotoxicity. In accordance with the time-dependent inhibitory effect of ZOR-CM, it has been demonstrated that tumor necrosis factor (TNF)-alpha was gradually accumulated in ZOR-CM by the induction of TNF-alpha mRNA expression in ZOR-stimulated RAW cells. Conversely, the inhibitory effect of ZOR-CM was reduced significantly by the removal of TNF-alpha after the formation of an immune complex with anti-TNF-alpha monoclonal antibody. These data suggested that ZOR itself has no inhibitory effect on the growth of influenza virus, but could exert its effect via macrophage activation leading to production of TNF-alpha.
|*Zingiber officinale[MESH]
|Animals[MESH]
|Antibodies, Monoclonal[MESH]
|Cell Line[MESH]
|Dogs[MESH]
|Dose-Response Relationship, Drug[MESH]
|Drugs, Chinese Herbal/*pharmacology[MESH]
|Influenza A Virus, H3N2 Subtype/*drug effects[MESH]