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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1254/jphs.fmj05003x3 http://scihub22266oqcxt.onion/10.1254/jphs.fmj05003x3 16397374!ä!16397374 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pharmacol+Sci 2006 ; 100 (1): 9-16 Nephropedia Template TP {{tp|p=16397374|t=2006. Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effects of aldosterone blockade |pdf=|usr=}}{{16397374}} gab.com Text Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effects of aldosterone blockade JO: J Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=16397374 #FOAvip Recent clinical and pre-clinical studies have indicated the utility of mineralocorticoid receptor (MR) antagonists in renal injury. We have demonstrated in rats that chronic treatment with aldosterone results in severe proteinuria and renal injury, characterized by glomerular changes, tubulointerstitial fibrosis, and collagen accumulation. We also observed increased reactive oxygen species (ROS) generation and mitogen-activated protein kinases (MAPKs) activity in renal cortical tissues. Treatment with a selective MR antagonist, eplerenone, prevented elevation of ROS levels and MAPK activity, as well as ameliorating renal injury. In vitro studies revealed that MRs are highly expressed in rat glomerular mesangial cells (RMC) and rat renal fibroblasts. In RMC, aldosterone induces cellular injuries through NADPH oxidase-dependent ROS production and/or MAPK activation. Aldosterone-induced renal cellular injuries were markedly attenuated by treatment with eplerenone. These data suggest that aldosterone induces renal injury through activation of MRs and support the notion that MR blockade has beneficial effects on aldosterone-dependent renal injury through mechanisms that cannot be simply explained by hemodynamic changes. In this review, we summarized our recent findings pertaining to the roles of aldosterone and MRs in the pathogenesis of renal injury. Potential molecular mechanisms responsible for aldosterone/MR-induced renal injury were also discussed. Twit Text FOAVip Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effects of aldosterone blockade ????J Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=16397374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16397374 #FOAvip English Wikipedia <ref>{{Cite pmid|16397374}}</ref> Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effects of aldosterone blockade #MMPMID16397374 Nishiyama A; Abe Y J Pharmacol Sci 2006[Jan]; 100 (1): 9-16 PMID16397374show ga Recent clinical and pre-clinical studies have indicated the utility of mineralocorticoid receptor (MR) antagonists in renal injury. We have demonstrated in rats that chronic treatment with aldosterone results in severe proteinuria and renal injury, characterized by glomerular changes, tubulointerstitial fibrosis, and collagen accumulation. We also observed increased reactive oxygen species (ROS) generation and mitogen-activated protein kinases (MAPKs) activity in renal cortical tissues. Treatment with a selective MR antagonist, eplerenone, prevented elevation of ROS levels and MAPK activity, as well as ameliorating renal injury. In vitro studies revealed that MRs are highly expressed in rat glomerular mesangial cells (RMC) and rat renal fibroblasts. In RMC, aldosterone induces cellular injuries through NADPH oxidase-dependent ROS production and/or MAPK activation. Aldosterone-induced renal cellular injuries were markedly attenuated by treatment with eplerenone. These data suggest that aldosterone induces renal injury through activation of MRs and support the notion that MR blockade has beneficial effects on aldosterone-dependent renal injury through mechanisms that cannot be simply explained by hemodynamic changes. In this review, we summarized our recent findings pertaining to the roles of aldosterone and MRs in the pathogenesis of renal injury. Potential molecular mechanisms responsible for aldosterone/MR-induced renal injury were also discussed. |*Mineralocorticoid Receptor Antagonists[MESH] |Aldosterone/toxicity[MESH] |Animals[MESH] |Cell Proliferation[MESH] |Cell Shape[MESH] |Cells, Cultured[MESH] |Collagen/metabolism[MESH] |Eplerenone[MESH] |Fibroblasts/metabolism[MESH] |Fibrosis[MESH] |Humans[MESH] |Kidney Diseases/chemically induced/drug therapy/enzymology[MESH] |Kidney/*drug effects/enzymology/pathology[MESH] |Mesangial Cells/*drug effects/metabolism[MESH] |Mitogen-Activated Protein Kinases/metabolism[MESH] |Rats[MESH] |Reactive Oxygen Species/metabolism[MESH] |Receptors, Mineralocorticoid/metabolism[MESH]Molecular mechanisms and therapeutic strategies of chronic renal injur(epmc).pdf DeepDyve Pubget Overpricing