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10.1152/ajprenal.00118.2005 http://scihub22266oqcxt.onion/10.1152/ajprenal.00118.2005 16275743!ä!16275743 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2005 ; 289 (6): F1159-69 Nephropedia Template TP {{tp|p=16275743|t=2005. An incredible decade for the primary cilium: a look at a once-forgotten organelle |pdf=|usr=}}{{16275743}} gab.com Text An incredible decade for the primary cilium: a look at a once-forgotten organelle JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=16275743 #FOAvip Since the discovery that numerous proteins involved in mammalian disease localize to the basal bodies and cilia, these organelles have emerged from relative obscurity to the center of intense research efforts in an expanding number of disease- and developmental-related fields. Our understanding of the association between cilia and human disease has benefited substantially from the use of lower organisms such as Chlamydomonas and Caenorhabditis elegans and the availability of murine models and cell culture. These research endeavors led to the discovery that loss of normal ciliary function in mammals is responsible for cystic and noncystic pathology in the kidney, liver, brain, and pancreas, as well as severe developmental patterning abnormalities. In addition, the localization of proteins involved in rare human disorders such as Bardet-Biedl syndrome has suggested that cilia-related dysfunction may play a role in modern human epidemics such as hypertension, obesity, and diabetes. Although we have made great advances in demonstrating the importance of cilia over the past decade, the physiological role that this organelle plays in most tissues remains elusive. Research focused on addressing this issue will be of critical importance for a further understanding of how ciliary dysfunction can lead to such severe disease and developmental pathologies. Twit Text FOAVip An incredible decade for the primary cilium: a look at a once-forgotten organelle ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=16275743 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16275743 #FOAvip English Wikipedia <ref>{{Cite pmid|16275743}}</ref> An incredible decade for the primary cilium: a look at a once-forgotten organelle #MMPMID16275743 Davenport JR; Yoder BK Am J Physiol Renal Physiol 2005[Dec]; 289 (6): F1159-69 PMID16275743show ga Since the discovery that numerous proteins involved in mammalian disease localize to the basal bodies and cilia, these organelles have emerged from relative obscurity to the center of intense research efforts in an expanding number of disease- and developmental-related fields. Our understanding of the association between cilia and human disease has benefited substantially from the use of lower organisms such as Chlamydomonas and Caenorhabditis elegans and the availability of murine models and cell culture. These research endeavors led to the discovery that loss of normal ciliary function in mammals is responsible for cystic and noncystic pathology in the kidney, liver, brain, and pancreas, as well as severe developmental patterning abnormalities. In addition, the localization of proteins involved in rare human disorders such as Bardet-Biedl syndrome has suggested that cilia-related dysfunction may play a role in modern human epidemics such as hypertension, obesity, and diabetes. Although we have made great advances in demonstrating the importance of cilia over the past decade, the physiological role that this organelle plays in most tissues remains elusive. Research focused on addressing this issue will be of critical importance for a further understanding of how ciliary dysfunction can lead to such severe disease and developmental pathologies. |Adaptor Proteins, Signal Transducing[MESH] |Animals[MESH] |Cilia/*physiology/ultrastructure[MESH] |Cytoskeletal Proteins[MESH] |Embryonic Development/physiology[MESH] |Humans[MESH] |Intracellular Signaling Peptides and Proteins/genetics[MESH] |Kartagener Syndrome/genetics[MESH] |Kidney Diseases/physiopathology[MESH] |Kinesins/genetics[MESH] |Liver/physiology/ultrastructure[MESH] |Mice[MESH] |Pancreas/physiology/ultrastructure[MESH] |Polycystic Kidney Diseases/genetics[MESH]An incredible decade for the primary cilium: a look at a once-forgotte(epmc).pdf DeepDyve Pubget Overpricing