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10.1371/journal.pmed.0020343 http://scihub22266oqcxt.onion/10.1371/journal.pmed.0020343 16253012!1274280!16253012     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Med 2005 ; 2 (12): e343 Nephropedia Template TP {{tp|p=16253012|t=2005. Prolonged activation of virus-specific CD8+T cells after acute B19 infection |pdf=|usr=}}{{16253012}} gab.com Text Prolonged activation of virus-specific CD8+T cells after acute B19 infection JO: PLoS Med http://www.kidney.de/pget.php?&tw=1&pmid=16253012 #FOAvip BACKGROUND: Human parvovirus B19 (B19) is a ubiquitous and clinically significant pathogen, causing erythema infectiosum, arthropathy, transient aplastic crisis, and intrauterine fetal death. The phenotype of CD8+ T cells in acute B19 infection has not been studied previously. METHODS AND FINDINGS: The number and phenotype of B19-specific CD8+ T cell responses during and after acute adult infection was studied using HLA-peptide multimeric complexes. Surprisingly, these responses increased in magnitude over the first year post-infection despite resolution of clinical symptoms and control of viraemia, with T cell populations specific for individual epitopes comprising up to 4% of CD8+ T cells. B19-specific T cells developed and maintained an activated CD38+ phenotype, with strong expression of perforin and CD57 and downregulation of CD28 and CD27. These cells possessed strong effector function and intact proliferative capacity. Individuals tested many years after infection exhibited lower frequencies of B19-specific cytotoxic T lymphocytes, typically 0.05%-0.5% of CD8+ T cells, which were perforin, CD38, and CCR7 low. CONCLUSION: This is the first example to our knowledge of an "acute" human viral infection inducing a persistent activated CD8+ T cell response. The likely explanation--analogous to that for cytomegalovirus infection--is that this persistent response is due to low-level antigen exposure. CD8+ T cells may contribute to the long-term control of this significant pathogen and should be considered during vaccine development. Twit Text FOAVip Prolonged activation of virus-specific CD8+T cells after acute B19 infection ????PLoS Med http://www.kidney.de/pget.php?&tw=1&pmid=16253012 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16253012 #FOAvip English Wikipedia <ref>{{Cite pmid|16253012}}</ref> Prolonged activation of virus-specific CD8+T cells after acute B19 infection #MMPMID16253012 Isa A; Kasprowicz V; Norbeck O; Loughry A; Jeffery K; Broliden K; Klenerman P; Tolfvenstam T; Bowness P PLoS Med 2005[Dec]; 2 (12): e343 PMID16253012show ga BACKGROUND: Human parvovirus B19 (B19) is a ubiquitous and clinically significant pathogen, causing erythema infectiosum, arthropathy, transient aplastic crisis, and intrauterine fetal death. The phenotype of CD8+ T cells in acute B19 infection has not been studied previously. METHODS AND FINDINGS: The number and phenotype of B19-specific CD8+ T cell responses during and after acute adult infection was studied using HLA-peptide multimeric complexes. Surprisingly, these responses increased in magnitude over the first year post-infection despite resolution of clinical symptoms and control of viraemia, with T cell populations specific for individual epitopes comprising up to 4% of CD8+ T cells. B19-specific T cells developed and maintained an activated CD38+ phenotype, with strong expression of perforin and CD57 and downregulation of CD28 and CD27. These cells possessed strong effector function and intact proliferative capacity. Individuals tested many years after infection exhibited lower frequencies of B19-specific cytotoxic T lymphocytes, typically 0.05%-0.5% of CD8+ T cells, which were perforin, CD38, and CCR7 low. CONCLUSION: This is the first example to our knowledge of an "acute" human viral infection inducing a persistent activated CD8+ T cell response. The likely explanation--analogous to that for cytomegalovirus infection--is that this persistent response is due to low-level antigen exposure. CD8+ T cells may contribute to the long-term control of this significant pathogen and should be considered during vaccine development. |ADP-ribosyl Cyclase 1/biosynthesis[MESH] |Acute Disease[MESH] |CD28 Antigens/biosynthesis[MESH] |CD57 Antigens/biosynthesis[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |Down-Regulation[MESH] |Erythema Infectiosum/*immunology[MESH] |Humans[MESH] |Parvovirus B19, Human/*pathogenicity[MESH] |Phenotype[MESH]Prolonged activation of virus-specific CD8+T cells after acute B19 inf(epmc).pdf DeepDyve Pubget Overpricing