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10.1186/1471-2334-5-78

http://scihub22266oqcxt.onion/10.1186/1471-2334-5-78
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suck abstract from ncbi


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pmid16191201      BMC+Infect+Dis 2005 ; 5 (ä): 78
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  • GB virus-C--a virus without a disease: we cannot give it chronic fatigue syndrome #MMPMID16191201
  • Jones JF; Kulkarni PS; Butera ST; Reeves WC
  • BMC Infect Dis 2005[Sep]; 5 (ä): 78 PMID16191201show ga
  • BACKGROUND: Chronic fatigue syndrome (CFS) is an illness in search of an infectious etiology. GB virus-C (GBV-C) virus is a flavivirus with cell tropism and host defense induction qualities compatible with a role in producing the syndrome. The GBV-C genome is detectable in 4% of the population and 12% of the population is seropositive. The present study evaluated the association between infection with GBV and CFS. METHODS: We used a commercial EIA to detect antibodies against the GBV-C E2 protein and a quantitative real-time RT-PCR assay to detect active GBV-C infection. Sera were from a case control study of CFS in Atlanta, Georgia. The Fisher's exact two-tailed test was used for statistical analysis. RESULTS: Two of 12 CFS patients and one of 21 controls were seropositive for prior GBV-C infection and one control had viral RNA detected, indicating active infection. The results are not statistically different. CONCLUSION: We found no evidence that active or past infection with GBV is associated with CFS.
  • |Antibodies, Viral/blood[MESH]
  • |Case-Control Studies[MESH]
  • |Fatigue Syndrome, Chronic/*virology[MESH]
  • |Female[MESH]
  • |Flaviviridae Infections/*virology[MESH]
  • |GB virus C/genetics/immunology/*isolation & purification/*pathogenicity[MESH]
  • |Humans[MESH]
  • |Male[MESH]


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