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10.1208/aapsj070115 http://scihub22266oqcxt.onion/10.1208/aapsj070115 16146336Ajulemicacid(IP-751):Synthesisproofofprincipletoxicitystudiesandclinicaltrials.!2751505!16146336; 751     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=16146336; 751&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 400 Bad Request in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AAPS+J;+Respir+Physiol 2005 ; 7; 24 (1; 1): E143-8; 1-13 Nephropedia Template TP {{tp|p=16146336; 751|t=2005. Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials ; Oxygen and carbon dioxide dissociation of duck blood |pdf=|usr=}}{{16146336; 751}} gab.com Text Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials ; Oxygen and carbon dioxide dissociation of duck blood JO: AAPS J; Respir Physiol http://www.kidney.de/pget.php?&tw=1&pmid=16146336; 751 #FOAvip Ajulemic acid (CT-3, IP-751, 1',1'-dimethylheptyl-Delta8-tetrahydrocannabinol-11-oic acid) (AJA) has a cannabinoid-derived structure; however, there is no evidence that it produces psychotropic actions when given at therapeutic doses. In a variety of animal assays, AJA shows efficacy in models for pain and inflammation. Furthermore, in the rat adjuvant arthritis model, it displayed a remarkable action in preventing the destruction of inflamed joints. A phase-2 human trial with chronic, neuropathic pain patients suggested that AJA could become a useful drug for treating this condition. Its low toxicity, particularly its lack of ulcerogenicity, further suggests that it will have a highly favorable therapeutic index and may replace some of the current anti-inflammatory/analgesic medications. Studies to date indicate a unique mechanism of action for AJA that may explain its lack of adverse side effects.; Oxygen and CO2 dissociation of duck blood was studied in blood samples equilibrated with known gas mixtures at the bird's body temperature (41 degrees C) and analyzed in the Van Slyke manometric apparatus and in pH electrodes. At various pH values between 7.38 and 7.55 the Hill plots yielded straight and parallel lines over a wide range of O2 saturation, the Hill coefficient being 2.9. Half saturation pressure P50 at pH = 7.50 was 36 torr. The Bohr effect factor was -0.53. Buffering properties were analyzed by equilibrating blood samples with gas mixtures of different PCO2 at 41 degrees C. The buffer value for whole blood in the range of 3-7% CO2 was 19.3 mMol-L-1-pH-1, the buffer value for true plasma 22.9 mMol-L-1-pH-1. The CO2 dissociation curve constructed using the buffer values had a slope of 0.17 mMol-L-1-torr-1 in the PCO2 range from 40 to 50 torr. The CO2 content of oxygenated blood at PCO2 = 40 torr was 21.7 mMol-L-1. The Haldane effect factor at PCO2 = 35 torr equalled 0.30 mMol of combined CO2 per mMol HbO2. With the values of PO2, PCO2 and pH measured in arterial blood of undisturbed and unrestrained, resting ducks effective dissociation curves for both O2 and CO2 were constructed assuming a metabolic R.Q. of 0.8. These curves are expected to resemble closely the actual in vitro dissociation curves of resting ducks. Twit Text FOAVip Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials ; Oxygen and carbon dioxide dissociation of duck blood ????AAPS J; Respir Physiol http://www.kidney.de/pget.php?&tw=1&pmid=16146336; 751 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16146336; 751 #FOAvip English Wikipedia <ref>{{Cite pmid|16146336; 751}}</ref> Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials ; Oxygen and carbon dioxide dissociation of duck blood #MMPMID16146336; 751 Burstein S; Scheipers G; Kawashiro T; Scheid P AAPS J; Respir Physiol 2005[Jun]; 7; 24 (1; 1): E143-8; 1-13 PMID16146336; 751show ga Ajulemic acid (CT-3, IP-751, 1',1'-dimethylheptyl-Delta8-tetrahydrocannabinol-11-oic acid) (AJA) has a cannabinoid-derived structure; however, there is no evidence that it produces psychotropic actions when given at therapeutic doses. In a variety of animal assays, AJA shows efficacy in models for pain and inflammation. Furthermore, in the rat adjuvant arthritis model, it displayed a remarkable action in preventing the destruction of inflamed joints. A phase-2 human trial with chronic, neuropathic pain patients suggested that AJA could become a useful drug for treating this condition. Its low toxicity, particularly its lack of ulcerogenicity, further suggests that it will have a highly favorable therapeutic index and may replace some of the current anti-inflammatory/analgesic medications. Studies to date indicate a unique mechanism of action for AJA that may explain its lack of adverse side effects.; Oxygen and CO2 dissociation of duck blood was studied in blood samples equilibrated with known gas mixtures at the bird's body temperature (41 degrees C) and analyzed in the Van Slyke manometric apparatus and in pH electrodes. At various pH values between 7.38 and 7.55 the Hill plots yielded straight and parallel lines over a wide range of O2 saturation, the Hill coefficient being 2.9. Half saturation pressure P50 at pH = 7.50 was 36 torr. The Bohr effect factor was -0.53. Buffering properties were analyzed by equilibrating blood samples with gas mixtures of different PCO2 at 41 degrees C. The buffer value for whole blood in the range of 3-7% CO2 was 19.3 mMol-L-1-pH-1, the buffer value for true plasma 22.9 mMol-L-1-pH-1. The CO2 dissociation curve constructed using the buffer values had a slope of 0.17 mMol-L-1-torr-1 in the PCO2 range from 40 to 50 torr. The CO2 content of oxygenated blood at PCO2 = 40 torr was 21.7 mMol-L-1. The Haldane effect factor at PCO2 = 35 torr equalled 0.30 mMol of combined CO2 per mMol HbO2. With the values of PO2, PCO2 and pH measured in arterial blood of undisturbed and unrestrained, resting ducks effective dissociation curves for both O2 and CO2 were constructed assuming a metabolic R.Q. of 0.8. These curves are expected to resemble closely the actual in vitro dissociation curves of resting ducks. |Adult[MESH] |Analgesics/adverse effects/chemical synthesis/pharmacology/therapeutic use/toxicity[MESH] |Animals[MESH] |Anti-Inflammatory Agents, Non-Steroidal/adverse effects/chemical synthesis/pharmacology/therapeutic use/toxicity[MESH] |Apoptosis/drug effects[MESH] |Arthritis, Experimental/drug therapy[MESH] |Buffers[MESH] |Cannabinoids/chemistry[MESH] |Carbon Dioxide/*blood[MESH] |Cell Line, Tumor/drug effects[MESH] |Clinical Trials, Phase II as Topic[MESH] |Cytokines/physiology[MESH] |Double-Blind Method[MESH] |Dronabinol/adverse effects/*analogs & derivatives/chemical synthesis/chemistry/pharmacology/therapeutic use/toxicity[MESH] |Drug Evaluation, Preclinical[MESH] |Ducks/*physiology[MESH] |Edema/drug therapy[MESH] |Female[MESH] |Gastritis/chemically induced[MESH] |Hemoglobins/*metabolism[MESH] |Humans[MESH] |Hydrogen-Ion Concentration[MESH] |Male[MESH] |Mice[MESH] |Middle Aged[MESH] |Molecular Structure[MESH] |Neuralgia/drug therapy[MESH] |Oxygen/*blood[MESH] |Randomized Controlled Trials as Topic[MESH]Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studie(epmc).pdf DeepDyve Pubget Overpricing