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10.1128/JVI.79.18.12117-12121.2005

http://scihub22266oqcxt.onion/10.1128/JVI.79.18.12117-12121.2005
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suck abstract from ncbi


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pmid16140790      J+Virol 2005 ; 79 (18): 12117-21
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  • Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans #MMPMID16140790
  • Norbeck O; Isa A; Pohlmann C; Broliden K; Kasprowicz V; Bowness P; Klenerman P; Tolfvenstam T
  • J Virol 2005[Sep]; 79 (18): 12117-21 PMID16140790show ga
  • Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.
  • |*Parvovirus B19, Human/genetics/immunology[MESH]
  • |Acute Disease[MESH]
  • |Adult[MESH]
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |Antigens, Viral/genetics[MESH]
  • |CD8-Positive T-Lymphocytes/*immunology[MESH]
  • |Capsid Proteins/genetics/immunology[MESH]
  • |Epitopes/genetics[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |Middle Aged[MESH]
  • |Molecular Sequence Data[MESH]
  • |Parvoviridae Infections/*immunology[MESH]
  • |Prospective Studies[MESH]
  • |Time Factors[MESH]


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