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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Virol 2005 ; 79 (18): 12117-21 Nephropedia Template TP
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Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans #MMPMID16140790
Norbeck O; Isa A; Pohlmann C; Broliden K; Kasprowicz V; Bowness P; Klenerman P; Tolfvenstam T
J Virol 2005[Sep]; 79 (18): 12117-21 PMID16140790show ga
Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.