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10.1038/labinvest.3700328 http://scihub22266oqcxt.onion/10.1038/labinvest.3700328 16127428!ä!16127428 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lab+Invest 2005 ; 85 (10): 1292-307 Nephropedia Template TP {{tp|p=16127428|t=2005. Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model |pdf=|usr=}}{{16127428}} gab.com Text Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model JO: Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=16127428 #FOAvip Tubulointerstitial hypoxia has been implicated in a number of progressive renal diseases, and several lines of evidence indicate that the administration of angiogenic growth factors ameliorates tubulointerstitial injury. We hypothesized that induction of hypoxia-inducible factors (HIF) mediates renoprotection by their angiogenic properties. At 5-9 weeks after subtotal nephrectomy, cobalt was administered to rats to activate HIF. Histological evaluation demonstrated that the tubulointerstitial injury was significantly ameliorated in animals that received cobalt (score: 2.51+/-0.12 (cobalt) vs 3.21+/-0.24 (vehicle), P<0.05). Furthermore, animals receiving cobalt had fewer vimentin- and TdT-mediated dUTP nick-end labeling (TUNEL)-positive tubular cells. The renoprotective effect of cobalt was associated with the preservation of peritubular capillary networks (rarefaction index: 13.7+/-0.4 (cobalt) vs 18.6+/-0.9 (vehicle), P<0.01). This improvement in capillary networks was accompanied by an increased number of proliferating (PCNA-positive) glomerular and peritubular endothelial cells. The angiogenesis produced by this method was not accompanied by an increase in vascular permeability. Furthermore, in vitro experiments clarified that HIF-1 in tubular epithelial cells promotes proliferation of endothelial cells and that HIF-2 overexpressed in renal endothelial cells mediates migration and network formation. Collectively, these findings demonstrate a renoprotective role of HIF through angiogenesis and provide a rationale for therapeutic approaches to target HIF for activation. Twit Text FOAVip Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model ????Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=16127428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16127428 #FOAvip English Wikipedia <ref>{{Cite pmid|16127428}}</ref> Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model #MMPMID16127428 Tanaka T; Kojima I; Ohse T; Ingelfinger JR; Adler S; Fujita T; Nangaku M Lab Invest 2005[Oct]; 85 (10): 1292-307 PMID16127428show ga Tubulointerstitial hypoxia has been implicated in a number of progressive renal diseases, and several lines of evidence indicate that the administration of angiogenic growth factors ameliorates tubulointerstitial injury. We hypothesized that induction of hypoxia-inducible factors (HIF) mediates renoprotection by their angiogenic properties. At 5-9 weeks after subtotal nephrectomy, cobalt was administered to rats to activate HIF. Histological evaluation demonstrated that the tubulointerstitial injury was significantly ameliorated in animals that received cobalt (score: 2.51+/-0.12 (cobalt) vs 3.21+/-0.24 (vehicle), P<0.05). Furthermore, animals receiving cobalt had fewer vimentin- and TdT-mediated dUTP nick-end labeling (TUNEL)-positive tubular cells. The renoprotective effect of cobalt was associated with the preservation of peritubular capillary networks (rarefaction index: 13.7+/-0.4 (cobalt) vs 18.6+/-0.9 (vehicle), P<0.01). This improvement in capillary networks was accompanied by an increased number of proliferating (PCNA-positive) glomerular and peritubular endothelial cells. The angiogenesis produced by this method was not accompanied by an increase in vascular permeability. Furthermore, in vitro experiments clarified that HIF-1 in tubular epithelial cells promotes proliferation of endothelial cells and that HIF-2 overexpressed in renal endothelial cells mediates migration and network formation. Collectively, these findings demonstrate a renoprotective role of HIF through angiogenesis and provide a rationale for therapeutic approaches to target HIF for activation. |*Neovascularization, Physiologic[MESH] |Animals[MESH] |Basic Helix-Loop-Helix Transcription Factors/*metabolism[MESH] |Capillaries/drug effects/pathology[MESH] |Capillary Permeability[MESH] |Cell Movement/drug effects[MESH] |Cell Proliferation/drug effects[MESH] |Cells, Cultured[MESH] |Cobalt/*pharmacology/therapeutic use[MESH] |Disease Models, Animal[MESH] |Endothelial Cells/drug effects/pathology/physiology[MESH] |Epithelial Cells/drug effects/pathology[MESH] |Female[MESH] |Hypoxia-Inducible Factor 1/*metabolism[MESH] |Hypoxia/*drug therapy/pathology/physiopathology[MESH] |In Situ Nick-End Labeling[MESH] |Kidney Diseases/*drug therapy/pathology/physiopathology[MESH] |Kidney Glomerulus/blood supply/drug effects/pathology[MESH] |Kidney Tubules/blood supply/drug effects/pathology[MESH] |Kidney/blood supply/*drug effects/pathology[MESH] |Nephrectomy[MESH] |Rats[MESH] |Rats, Wistar[MESH]Cobalt promotes angiogenesis via hypoxia-inducible factor and protects(epmc).pdf DeepDyve Pubget Overpricing