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10.1016/j.mrfmmm.2005.03.024 http://scihub22266oqcxt.onion/10.1016/j.mrfmmm.2005.03.024 16084533!ä!16084533 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mutat+Res 2005 ; 579 (1-2): 37-46 Nephropedia Template TP {{tp|p=16084533|t=2005. Advanced glycoxidation end products in chronic diseases-clinical chemistry and genetic background |pdf=|usr=}}{{16084533}} gab.com Text Advanced glycoxidation end products in chronic diseases-clinical chemistry and genetic background JO: Mutat Res http://www.kidney.de/pget.php?&tw=1&pmid=16084533 #FOAvip Several diseases (atherosclerosis, diabetes mellitus, chronic renal failure) are associated with oxidative and carbonyl stress, microinflammation and eventually autoimmune reaction. Both oxidative and carbonyl stress cause damage to important biological structures-proteins, carbohydrates, lipids and nucleic acids and may enhance inflammatory response. New compounds and modified structures are formed, among them advanced oxidation protein products (AOPP), advanced glycation end products (AGEs-e.g. pentosidine, carboxymethyllysine) and advanced lipoperoxidation end products (ALEs). Accumulation of glycoxidation products, upregulation of protective mechanisms like glyoxalase I as well as enhanced transcription of genes coding for cytokines, growth factors and adhesive molecules via AGE-RAGE (receptor for AGEs) interaction and subsequent increase of classical acute phase reactants (e.g. CRP-C-reactive protein or orosomucoid) can be observed in a variety of chronic diseases. Additionally, several RAGE gene polymorphisms have shown association with some pathological states-diabetic complications, vascular damage, inflammatory response or antioxidant status. Recent advances in understanding the pathogenesis of chronic diseases provide new possibilities for diagnostics and monitoring of severely ill patients, however, further studies are still required to establish efficient therapeutical strategies. Twit Text FOAVip Advanced glycoxidation end products in chronic diseases-clinical chemistry and genetic background ????Mutat Res http://www.kidney.de/pget.php?&tw=1&pmid=16084533 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16084533 #FOAvip English Wikipedia <ref>{{Cite pmid|16084533}}</ref> Advanced glycoxidation end products in chronic diseases-clinical chemistry and genetic background #MMPMID16084533 Kalousova M; Zima T; Tesar V; Dusilova-Sulkova S; Skrha J Mutat Res 2005[Nov]; 579 (1-2): 37-46 PMID16084533show ga Several diseases (atherosclerosis, diabetes mellitus, chronic renal failure) are associated with oxidative and carbonyl stress, microinflammation and eventually autoimmune reaction. Both oxidative and carbonyl stress cause damage to important biological structures-proteins, carbohydrates, lipids and nucleic acids and may enhance inflammatory response. New compounds and modified structures are formed, among them advanced oxidation protein products (AOPP), advanced glycation end products (AGEs-e.g. pentosidine, carboxymethyllysine) and advanced lipoperoxidation end products (ALEs). Accumulation of glycoxidation products, upregulation of protective mechanisms like glyoxalase I as well as enhanced transcription of genes coding for cytokines, growth factors and adhesive molecules via AGE-RAGE (receptor for AGEs) interaction and subsequent increase of classical acute phase reactants (e.g. CRP-C-reactive protein or orosomucoid) can be observed in a variety of chronic diseases. Additionally, several RAGE gene polymorphisms have shown association with some pathological states-diabetic complications, vascular damage, inflammatory response or antioxidant status. Recent advances in understanding the pathogenesis of chronic diseases provide new possibilities for diagnostics and monitoring of severely ill patients, however, further studies are still required to establish efficient therapeutical strategies. |*Chronic Disease[MESH] |Chemistry, Clinical/*methods[MESH] |Diabetes Mellitus/genetics/metabolism[MESH] |Glycation End Products, Advanced/*analysis/metabolism[MESH] |Humans[MESH] |Inflammation/etiology/metabolism[MESH] |Kidney Failure, Chronic/complications/metabolism[MESH] |Lactoylglutathione Lyase/genetics/metabolism[MESH] |Nucleotides/metabolism[MESH] |Oxidation-Reduction[MESH] |Oxidative Stress[MESH] |Polymorphism, Genetic[MESH] |Receptor for Advanced Glycation End Products[MESH] |Receptors, Cytoplasmic and Nuclear/metabolism[MESH]Advanced glycoxidation end products in chronic diseases-clinical chemi(epmc).pdf DeepDyve Pubget Overpricing