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10.3201/1107.050219

http://scihub22266oqcxt.onion/10.3201/1107.050219
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16022774!3371787!16022774
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suck abstract from ncbi

pmid16022774      Emerg+Infect+Dis 2005 ; 11 (7): 1016-20
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  • SARS vaccine development #MMPMID16022774
  • Jiang S; He Y; Liu S
  • Emerg Infect Dis 2005[Jul]; 11 (7): 1016-20 PMID16022774show ga
  • Developing effective and safe vaccines is urgently needed to prevent infection by severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV). The inactivated SARS-CoV vaccine may be the first one available for clinical use because it is easy to generate; however, safety is the main concern. The spike (S) protein of SARS-CoV is the major inducer of neutralizing antibodies, and the receptor-binding domain (RBD) in the S1 subunit of S protein contains multiple conformational neutralizing epitopes. This suggests that recombinant proteins containing RBD and vectors encoding the RBD sequence can be used to develop safe and effective SARS vaccines.
  • |*Viral Vaccines[MESH]
  • |Epitopes[MESH]
  • |Humans[MESH]
  • |Membrane Glycoproteins/immunology[MESH]
  • |Severe Acute Respiratory Syndrome/*prevention & control[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/*immunology[MESH]
  • |Spike Glycoprotein, Coronavirus[MESH]
  • |Vaccines, Inactivated[MESH]


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