Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.0504422102 http://scihub22266oqcxt.onion/10.1073/pnas.0504422102 16006511!1177404!16006511     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=16006511&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2005 ; 102 (29): 10315-20 Nephropedia Template TP {{tp|p=16006511|t=2005. WNK1 activates SGK1 to regulate the epithelial sodium channel |pdf=|usr=}}{{16006511}} gab.com Text WNK1 activates SGK1 to regulate the epithelial sodium channel JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=16006511 #FOAvip WNK (with no lysine [K]) kinases are serine-threonine protein kinases with an atypical placement of the catalytic lysine. Intronic deletions increase the expression of WNK1 in humans and cause pseudohypoaldosteronism type II, a form of hypertension. WNKs have been linked to ion carriers, but the underlying regulatory mechanisms are unknown. Here, we report a mechanism for the control of ion permeability by WNK1. We show that WNK1 activates the serum- and glucocorticoid-inducible protein kinase SGK1, leading to activation of the epithelial sodium channel. Increased channel activity induced by WNK1 depends on SGK1 and the E3 ubiquitin ligase Nedd4-2. This finding provides compelling evidence that this molecular mechanism contributes to the pathogenesis of hypertension in pseudohypoaldosteronism type II caused by WNK1 and, possibly, in other forms of hypertension. Twit Text FOAVip WNK1 activates SGK1 to regulate the epithelial sodium channel ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=16006511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16006511 #FOAvip English Wikipedia <ref>{{Cite pmid|16006511}}</ref> WNK1 activates SGK1 to regulate the epithelial sodium channel #MMPMID16006511 Xu BE; Stippec S; Chu PY; Lazrak A; Li XJ; Lee BH; English JM; Ortega B; Huang CL; Cobb MH Proc Natl Acad Sci U S A 2005[Jul]; 102 (29): 10315-20 PMID16006511show ga WNK (with no lysine [K]) kinases are serine-threonine protein kinases with an atypical placement of the catalytic lysine. Intronic deletions increase the expression of WNK1 in humans and cause pseudohypoaldosteronism type II, a form of hypertension. WNKs have been linked to ion carriers, but the underlying regulatory mechanisms are unknown. Here, we report a mechanism for the control of ion permeability by WNK1. We show that WNK1 activates the serum- and glucocorticoid-inducible protein kinase SGK1, leading to activation of the epithelial sodium channel. Increased channel activity induced by WNK1 depends on SGK1 and the E3 ubiquitin ligase Nedd4-2. This finding provides compelling evidence that this molecular mechanism contributes to the pathogenesis of hypertension in pseudohypoaldosteronism type II caused by WNK1 and, possibly, in other forms of hypertension. |Animals[MESH] |CHO Cells[MESH] |Cells, Cultured[MESH] |Cricetinae[MESH] |Cricetulus[MESH] |Endosomal Sorting Complexes Required for Transport[MESH] |Enzyme Activation/physiology[MESH] |Epithelial Sodium Channels[MESH] |Humans[MESH] |Immediate-Early Proteins/*metabolism[MESH] |Immunoblotting[MESH] |Immunoprecipitation[MESH] |Intracellular Signaling Peptides and Proteins[MESH] |Minor Histocompatibility Antigens[MESH] |Nedd4 Ubiquitin Protein Ligases[MESH] |Patch-Clamp Techniques[MESH] |Protein Serine-Threonine Kinases/*metabolism[MESH] |Pseudohypoaldosteronism/metabolism/*physiopathology[MESH] |Sodium Channels/*metabolism[MESH] |Two-Hybrid System Techniques[MESH] |Ubiquitin-Protein Ligases/metabolism[MESH]WNK1 activates SGK1 to regulate the epithelial sodium channel (epmc).pdf DeepDyve Pubget Overpricing