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10.1681/ASN.V210s139 http://scihub22266oqcxt.onion/10.1681/ASN.V210s139 1600129!ä!1600129 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 1992 ; 2 (10 Suppl): S139-43 Nephropedia Template TP {{tp|p=1600129|t=1992. Immune damage to the mesangium: antibody- and complement-mediated stimulation and destruction of mesangial cells |pdf=|usr=}}{{1600129}} gab.com Text Immune damage to the mesangium: antibody- and complement-mediated stimulation and destruction of mesangial cells JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=1600129 #FOAvip The deposition of immune complexes in the tissue results in complement activation leading to the formation of the lytic C5b-9 complex. Tissue cells are relatively resistant to complement attack due to cellular mechanisms such as removing C5b-9 from the surface and the expression of membrane proteins, which regulate complement activation and attack on the cell surface. Hence, cell killing is not an important consequence of complement activation on nucleated cells. On the other hand, the sublethal C5b-9-membrane interaction leads to various cellular responses, among them the synthesis of eicosanoids, cytokines, matrix-degrading proteases, and extracellular matrix, resulting in the modification of cell proliferation, leukocyte function, matrix degradation, and the formation of scar tissue. Thus, the complement-dependent immune damage is caused by secondary mediators, either derived from leukocytes or mesangial cells, rather than by a direct C5b-9-mediated killing. Twit Text FOAVip Immune damage to the mesangium: antibody- and complement-mediated stimulation and destruction of mesangial cells ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=1600129 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=1600129 #FOAvip English Wikipedia <ref>{{Cite pmid|1600129}}</ref> Immune damage to the mesangium: antibody- and complement-mediated stimulation and destruction of mesangial cells #MMPMID1600129 Hansch GM; Schieren G; Wagner C; Schonermark M J Am Soc Nephrol 1992[Apr]; 2 (10 Suppl): S139-43 PMID1600129show ga The deposition of immune complexes in the tissue results in complement activation leading to the formation of the lytic C5b-9 complex. Tissue cells are relatively resistant to complement attack due to cellular mechanisms such as removing C5b-9 from the surface and the expression of membrane proteins, which regulate complement activation and attack on the cell surface. Hence, cell killing is not an important consequence of complement activation on nucleated cells. On the other hand, the sublethal C5b-9-membrane interaction leads to various cellular responses, among them the synthesis of eicosanoids, cytokines, matrix-degrading proteases, and extracellular matrix, resulting in the modification of cell proliferation, leukocyte function, matrix degradation, and the formation of scar tissue. Thus, the complement-dependent immune damage is caused by secondary mediators, either derived from leukocytes or mesangial cells, rather than by a direct C5b-9-mediated killing. |Animals[MESH] |Antibodies[MESH] |Complement Activation[MESH] |Complement Membrane Attack Complex[MESH] |Glomerular Mesangium/*immunology/injuries[MESH] |Humans[MESH]Immune damage to the mesangium: antibody- and complement-mediated stim(epmc).pdf DeepDyve Pubget Overpricing