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http://scihub22266oqcxt.onion/ 15932674!?!15932674 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538       Zhonghua+Xin+Xue+Guan+Bing+Za+Zhi 2005 ; 33 (4): 364-8 Nephropedia Template TP {{tp|p=15932674|t=2005. Calmodulin antagonist inhibits torsade de pointes induced by d-sotalol in an isolated rabbit heart model |pdf=|usr=}}{{15932674}} gab.com Text Calmodulin antagonist inhibits torsade de pointes induced by d-sotalol in an isolated rabbit heart model JO: Zhonghua Xin Xue Guan Bing Za Zhi http://www.kidney.de/pget.php?&tw=1&pmid=15932674 #FOAvip OBJECTIVE: To evaluate the effects of W-7, a calmodulin inhibitor, on transmural dispersion of repolarization (TDR), early after depolarization (EAD) and torsade de pointes (TdP) induction after administration of d-sotalol in isolated rabbit heart. METHODS: TdP was induced by d-sotalol (30 micromol/L), bradycardia, and hypokalemic (1.5 mmol/L)/hypomagnesaemic (0.35 mmol/L) solution in isolated female rabbit hearts. Thirty six rabbit hearts were divided into 4 groups (n = 9 each): d-sotalol alone, d-sotalol + W-7 (20 micromol/L), d-sotalol + W-7 (50 micromol/L), and d-sotalol + W-7 (100 micromol/L). Monophasic action potentials (MAPs) of the left ventricular epimyocardium (Epi), midmyocardium (M), and endomyocardium (Endo) were recorded simultaneously with ECG. The incidence of EAD and TdP were observed as well. RESULTS: Treatment with d-sotalol alone prolonged ventricular MAP duration and QT interval, increased TDR, and evoked high incidence of EAD (9/9) and spontaneous TdP (7/9) in hypokalemic/hypomagnesaemic solution in female rabbit heart. W-7 concentration-dependently decreased incidence of TdP (4/9 in 20 micromol/L; 2/9 in 50 micromol/L; 1/9 in 100 micromol/L). This effect of W-7 coincided with the decreased incidence of EAD (5/9 in 20 micromol/L; 4/9 in 50 micromol/L; 1/9 in 100 micromol/L). However, the d-sotalol-induced prolongation of QT interval and TDR was not significantly altered by W-7 at the three concentration used. CONCLUSIONS: In isolated female rabbit hearts, calmodulin antagonist W-7 suppresses d-sotalol-induced TdP without altering TDR but does suppress EAD. The effects observed with W-7 also suggest a possible important role for calmodulin-activated enzymes in the induction of TdP. Twit Text FOAVip Calmodulin antagonist inhibits torsade de pointes induced by d-sotalol in an isolated rabbit heart model ????Zhonghua Xin Xue Guan Bing Za Zhi http://www.kidney.de/pget.php?&tw=1&pmid=15932674 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15932674 #FOAvip English Wikipedia <ref>{{Cite pmid|15932674}}</ref> Calmodulin antagonist inhibits torsade de pointes induced by d-sotalol in an isolated rabbit heart model #MMPMID15932674 Pu J; Zhang CT; Bai R; Liu N; Li Y; Wang L Zhonghua Xin Xue Guan Bing Za Zhi 2005[Apr]; 33 (4): 364-8 PMID15932674show ga OBJECTIVE: To evaluate the effects of W-7, a calmodulin inhibitor, on transmural dispersion of repolarization (TDR), early after depolarization (EAD) and torsade de pointes (TdP) induction after administration of d-sotalol in isolated rabbit heart. METHODS: TdP was induced by d-sotalol (30 micromol/L), bradycardia, and hypokalemic (1.5 mmol/L)/hypomagnesaemic (0.35 mmol/L) solution in isolated female rabbit hearts. Thirty six rabbit hearts were divided into 4 groups (n = 9 each): d-sotalol alone, d-sotalol + W-7 (20 micromol/L), d-sotalol + W-7 (50 micromol/L), and d-sotalol + W-7 (100 micromol/L). Monophasic action potentials (MAPs) of the left ventricular epimyocardium (Epi), midmyocardium (M), and endomyocardium (Endo) were recorded simultaneously with ECG. The incidence of EAD and TdP were observed as well. RESULTS: Treatment with d-sotalol alone prolonged ventricular MAP duration and QT interval, increased TDR, and evoked high incidence of EAD (9/9) and spontaneous TdP (7/9) in hypokalemic/hypomagnesaemic solution in female rabbit heart. W-7 concentration-dependently decreased incidence of TdP (4/9 in 20 micromol/L; 2/9 in 50 micromol/L; 1/9 in 100 micromol/L). This effect of W-7 coincided with the decreased incidence of EAD (5/9 in 20 micromol/L; 4/9 in 50 micromol/L; 1/9 in 100 micromol/L). However, the d-sotalol-induced prolongation of QT interval and TDR was not significantly altered by W-7 at the three concentration used. CONCLUSIONS: In isolated female rabbit hearts, calmodulin antagonist W-7 suppresses d-sotalol-induced TdP without altering TDR but does suppress EAD. The effects observed with W-7 also suggest a possible important role for calmodulin-activated enzymes in the induction of TdP. |Animals[MESH] |Calmodulin/antagonists & inhibitors[MESH] |Enzyme Inhibitors/*therapeutic use[MESH] |Female[MESH] |In Vitro Techniques[MESH] |Rabbits[MESH] |Sotalol/adverse effects[MESH] |Sulfonamides/*therapeutic use[MESH] Calmodulin antagonist inhibits torsade de pointes induced by d-sotalo(epmc).pdf DeepDyve Pubget Overpricing