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10.1002/path.1769 http://scihub22266oqcxt.onion/10.1002/path.1769 15892035!7167940!15892035     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pathol 2005 ; 206 (3): 251-9 Nephropedia Template TP {{tp|p=15892035|t=2005. An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus |pdf=|usr=}}{{15892035}} gab.com Text An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus JO: J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=15892035 #FOAvip A new SARS animal model was established by inoculating SARS coronavirus (SARS-CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5-60 after virus inoculation. All eight animals showed a transient fever 2-3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS-CoV-specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS-CoV RNA could be detected in pharyngeal swab samples using nested RT-PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS-CoV-related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS. Twit Text FOAVip An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus ????J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=15892035 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15892035 #FOAvip English Wikipedia <ref>{{Cite pmid|15892035}}</ref> An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus #MMPMID15892035 Qin C; Wang J; Wei Q; She M; Marasco WA; Jiang H; Tu X; Zhu H; Ren L; Gao H; Guo L; Huang L; Yang R; Cong Z; Guo L; Wang Y; Liu Y; Sun Y; Duan S; Qu J; Chen L; Tong W; Ruan L; Liu P; Zhang H; Zhang J; Zhang H; Liu D; Liu Q; Hong T; He W J Pathol 2005[Jul]; 206 (3): 251-9 PMID15892035show ga A new SARS animal model was established by inoculating SARS coronavirus (SARS-CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5-60 after virus inoculation. All eight animals showed a transient fever 2-3 days after inoculation. Immunological, molecular biological, and pathological studies support the establishment of this SARS animal model. Firstly, SARS-CoV-specific IgGs were detected in the sera of macaques from 11 to 60 days after inoculation. Secondly, SARS-CoV RNA could be detected in pharyngeal swab samples using nested RT-PCR in all infected animals from 5 days after virus inoculation. Finally, histopathological changes of interstitial pneumonia were found in the lungs during the 60 days after viral inoculation: these changes were less marked at later time points, indicating that an active healing process together with resolution of an acute inflammatory response was taking place in these animals. This animal model should provide insight into the mechanisms of SARS-CoV-related pulmonary disease and greatly facilitate the development of vaccines and therapeutics against SARS. |*Disease Models, Animal[MESH] |*Severe acute respiratory syndrome-related coronavirus[MESH] |Animals[MESH] |Hemorrhage/complications/pathology[MESH] |Immunoglobulin G/blood[MESH] |Lung Diseases, Interstitial/complications/pathology[MESH] |Lung/pathology[MESH] |Lymphocytes/pathology[MESH] |Macaca mulatta[MESH] |Macrophages/pathology[MESH] |Microscopy, Electron/methods[MESH] |Pharynx/virology[MESH] |Pulmonary Alveoli/pathology[MESH] |RNA, Viral/analysis[MESH] |Severe Acute Respiratory Syndrome/blood/pathology/*virology[MESH]An animal model of SARS produced by infection of Macaca mulatta with S(epmc).pdf DeepDyve Pubget Overpricing