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10.1007/BF02454195

http://scihub22266oqcxt.onion/10.1007/BF02454195
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1584207!ä!1584207

suck abstract from ncbi


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pmid1584207      Mol+Cell+Biochem 1992 ; 110 (2): 169-73
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  • Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin #MMPMID1584207
  • Weglicki WB; Phillips TM; Freedman AM; Cassidy MM; Dickens BF
  • Mol Cell Biochem 1992[Mar]; 110 (2): 169-73 PMID1584207show ga
  • We have developed two rodent models of diet-induced magnesium-deficiency in which histologically defined cardiac lesions can be induced within two to three weeks. During the development of these lesions, the magnesium-deficient animals exhibit circulating cytokine levels which are indicative of a generalized inflammatory state. Dramatic elevations of the macrophage-derived cytokines, IL-1, IL-6, and TNF-alpha together with significantly elevated levels of the endothelial cell-derived cytokine, endothelin, were detected in the plasma of these animals. We believe that the pathophysiological effects caused by the action of these cytokines may play a role in the promotion of cardiovascular pathology associated with magnesium deficiency.
  • |Animals[MESH]
  • |Cardiovascular Diseases/etiology/pathology[MESH]
  • |Cricetinae[MESH]
  • |Cytokines/*blood[MESH]
  • |Endothelins/*blood[MESH]
  • |Female[MESH]
  • |Magnesium Deficiency/*blood/complications[MESH]
  • |Male[MESH]
  • |Mesocricetus[MESH]
  • |Rats[MESH]


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