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10.2741/1610 http://scihub22266oqcxt.onion/10.2741/1610 15769616!ä!15769616 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Biosci 2005 ; 10 (ä): 1177-82 Nephropedia Template TP {{tp|p=15769616|t=2005. Magnesium and microvascular endothelial cells: a role in inflammation and angiogenesis |pdf=|usr=}}{{15769616}} gab.com Text Magnesium and microvascular endothelial cells: a role in inflammation and angiogenesis JO: Front Biosci http://www.kidney.de/pget.php?&tw=1&pmid=15769616 #FOAvip Microvascular endothelial cells are protagonists in inflammation and angiogenesis. Since magnesium (Mg) deficiency promotes inflammation and impairs angiogenesis in vivo, we evaluated the effect of different concentrations of the cation on microvascular 1G11 cells. We found that low Mg inhibits endothelial growth and migration, while it increases some inflammatory markers. In particular we show that low Mg stimulates the synthesis of interleukin 1a and 6, of nitric oxide, a mediator of inflammatory responses, and of VCAM, which mediates monocyte/endothelial interactions. On the contrary, high Mg stimulates proliferation and migration and sensitizes microvascular cells to migratory signals, thus inducing crucial events in angiogenesis. Our results demonstrate a direct role of Mg in modulating microvascular functions and provide a molecular explanation to the link among Mg, angiogenesis and inflammation observed in in vivo models. Twit Text FOAVip Magnesium and microvascular endothelial cells: a role in inflammation and angiogenesis ????Front Biosci http://www.kidney.de/pget.php?&tw=1&pmid=15769616 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15769616 #FOAvip English Wikipedia <ref>{{Cite pmid|15769616}}</ref> Magnesium and microvascular endothelial cells: a role in inflammation and angiogenesis #MMPMID15769616 Bernardini D; Nasulewic A; Mazur A; Maier JA Front Biosci 2005[May]; 10 (ä): 1177-82 PMID15769616show ga Microvascular endothelial cells are protagonists in inflammation and angiogenesis. Since magnesium (Mg) deficiency promotes inflammation and impairs angiogenesis in vivo, we evaluated the effect of different concentrations of the cation on microvascular 1G11 cells. We found that low Mg inhibits endothelial growth and migration, while it increases some inflammatory markers. In particular we show that low Mg stimulates the synthesis of interleukin 1a and 6, of nitric oxide, a mediator of inflammatory responses, and of VCAM, which mediates monocyte/endothelial interactions. On the contrary, high Mg stimulates proliferation and migration and sensitizes microvascular cells to migratory signals, thus inducing crucial events in angiogenesis. Our results demonstrate a direct role of Mg in modulating microvascular functions and provide a molecular explanation to the link among Mg, angiogenesis and inflammation observed in in vivo models. |Animals[MESH] |Cell Movement/drug effects[MESH] |Cell Proliferation/drug effects[MESH] |Cells, Cultured[MESH] |Cytokines/metabolism[MESH] |Endothelium, Vascular/cytology/*drug effects/physiology[MESH] |Inflammation/*physiopathology[MESH] |Magnesium/*pharmacology[MESH] |Mice[MESH] |Neovascularization, Physiologic/*physiology[MESH]Magnesium and microvascular endothelial cells: a role in inflammation (epmc).pdf DeepDyve Pubget Overpricing