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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Comp+Pathol 2005 ; 132 (2-3): 179-84 Nephropedia Template TP
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Pathogenesis of swine influenza virus subtype H1N2 infection in pigs #MMPMID15737344
Jung K; Ha Y; Chae C
J Comp Pathol 2005[Feb]; 132 (2-3): 179-84 PMID15737344show ga
The purpose of this study was to elucidate pathogenesis and viral distribution in pigs infected with swine influenza virus subtype H1N2, over a period of 10 days, by morphometric analysis and in-situ hybridization. Fifteen colostrum-deprived pigs aged 3 weeks were inoculated intranasally with virus. Pneumonia was severe at 1 day post-inoculation (dpi), moderate at 3 and 5 dpi, and mild at 7 and 10 dpi. The pulmonary lesion score was correlated with the score of cells positive by in-situ hybridization for swine influenza virus (r(s)= 0.9114, P< 0.05). The distribution of swine influenza virus varied according to the duration of infection. At 1 and 3 dpi, hybridization signals were detected mainly in the bronchial and bronchiolar epithelial cells, but they were detected mainly in the pneumocytes and macrophages (alveolar and interstitial) at 7 and 10 dpi. The results confirmed that swine influenza virus subtype H1N2, isolated in Korea, is a virulent pathogen causing severe pneumonia.
|Animals[MESH]
|Animals, Newborn[MESH]
|Bronchi/pathology/virology[MESH]
|Cell Count/veterinary[MESH]
|Epithelium/pathology/virology[MESH]
|In Situ Hybridization/veterinary[MESH]
|Influenza A virus/genetics/isolation & purification/*pathogenicity[MESH]
J+Comp+Pathol 2005 ; 132 (2-3): 179-84
