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http://scihub22266oqcxt.onion/ 15726901!ä!15726901 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=15726901&cmd=llinks): Failed to open stream: HTTP request failed! 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Changes in gene expression in the lungs of Mg-deficient mice are related to an inflammatory process |pdf=|usr=}}{{15726901}} gab.com Text Changes in gene expression in the lungs of Mg-deficient mice are related to an inflammatory process JO: Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=15726901 #FOAvip It has been well documented that experimental hypomagnesemia in rodents evokes, as an early consequence, an inflammatory response. This also leads to the activation of cells producing reactive species of oxygen and, as a result, to the oxidative damage of tissues. Several studies have shown that lungs might be a specific target of Mg deficiency. Here, we report that 3 weeks of Mg deficiency in mice resulted in inflammatory processes in the lungs, including interstitial and perivascular pneumonia, manifested by the infiltration of leukocytes, plasmocytes and histiocytes, as well as the phenomenon of disseminated intravascular coagulation (DIC). These phenomena were accompanied by changes in gene expression assessed by cDNA array. In this study we identified 26 genes significantly changed by Mg deficiency, mostly involved in the anti-oxidative response, regulation of cell cycle and growth, apoptosis as well as cell-cell and cell-matrix interactions. We conclude that these changes are related to the phenomena of inflammatory and oxidative processes and consecutive remodeling occurring in the tissues as a result of Mg deficiency. This may have implications for at least several lung pathologies, including allergies, asthma, SIDS (Sudden Infant Death Syndrome) or facilitate formation of lung metastases. Twit Text FOAVip Changes in gene expression in the lungs of Mg-deficient mice are related to an inflammatory process ????Magnes Res http://www.kidney.de/pget.php?&tw=1&pmid=15726901 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15726901 #FOAvip English Wikipedia <ref>{{Cite pmid|15726901}}</ref> Changes in gene expression in the lungs of Mg-deficient mice are related to an inflammatory process #MMPMID15726901 Nasulewicz A; Zimowska W; Bayle D; Dzimira S; Madej J; Rayssiguier Y; Opolski A; Mazur A Magnes Res 2004[Dec]; 17 (4): 259-63 PMID15726901show ga It has been well documented that experimental hypomagnesemia in rodents evokes, as an early consequence, an inflammatory response. This also leads to the activation of cells producing reactive species of oxygen and, as a result, to the oxidative damage of tissues. Several studies have shown that lungs might be a specific target of Mg deficiency. Here, we report that 3 weeks of Mg deficiency in mice resulted in inflammatory processes in the lungs, including interstitial and perivascular pneumonia, manifested by the infiltration of leukocytes, plasmocytes and histiocytes, as well as the phenomenon of disseminated intravascular coagulation (DIC). These phenomena were accompanied by changes in gene expression assessed by cDNA array. In this study we identified 26 genes significantly changed by Mg deficiency, mostly involved in the anti-oxidative response, regulation of cell cycle and growth, apoptosis as well as cell-cell and cell-matrix interactions. We conclude that these changes are related to the phenomena of inflammatory and oxidative processes and consecutive remodeling occurring in the tissues as a result of Mg deficiency. This may have implications for at least several lung pathologies, including allergies, asthma, SIDS (Sudden Infant Death Syndrome) or facilitate formation of lung metastases. |Animals[MESH] |Down-Regulation[MESH] |Female[MESH] |Gene Expression/*physiology[MESH] |Inflammation/*metabolism[MESH] |Leukocytes/metabolism[MESH] |Lung/*metabolism[MESH] |Magnesium/*blood[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Oligonucleotide Array Sequence Analysis[MESH] |Oxidative Stress/genetics/physiology[MESH]Changes in gene expression in the lungs of Mg-deficient mice are relat(epmc).pdf DeepDyve Pubget Overpricing