Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4049/jimmunol.174.4.1932 http://scihub22266oqcxt.onion/10.4049/jimmunol.174.4.1932 15699120!ä!15699120 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2005 ; 174 (4): 1932-7 Nephropedia Template TP {{tp|p=15699120|t=2005. IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29 |pdf=|usr=}}{{15699120}} gab.com Text IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=15699120 #FOAvip Toll-like receptors (TLRs) mediate host cell activation by various microbial components. TLR2, TLR3, TLR4, TLR7, TLR8, and TLR9 are the receptors that have been associated with virus-induced immune response. We have previously reported that all these TLRs, except TLR9, are expressed at mRNA levels in human monocyte-derived macrophages. Here we have studied TLR2, TLR3, TLR4, and TLR7/8 ligand-induced IFN-alpha, IFN-beta, IL-28, and IL-29 expression in human macrophages. IFN-alpha pretreatment of macrophages was required for efficient TLR3 and TLR4 agonist-induced activation of IFN-alpha, IFN-beta, IL-28, and IL-29 genes. TLR7/8 agonist weakly activated IFN-alpha, IFN-beta, IL-28, and IL-29 genes, whereas TLR2 agonist was not able to activate these genes. IFN-alpha enhanced TLR responsiveness in macrophages by up-regulating the expression of TLR3, TLR4, and TLR7. IFN-alpha also enhanced the expression of TLR signaling molecules MyD88, TIR domain-containing adaptor inducing IFN-beta, IkappaB kinase-epsilon, receptor interacting protein 1, and IFN regulatory factor 7. Furthermore, the activation of transcription factor IFN regulatory factor 3 by TLR3 and TLR4 agonists was dependent on IFN-alpha pretreatment. In conclusion, our results suggest that IFN-alpha sensitizes cells to microbial recognition by up-regulating the expression of several TLRs as well as adapter molecules and kinases involved in TLR signaling. Twit Text FOAVip IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=15699120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15699120 #FOAvip English Wikipedia <ref>{{Cite pmid|15699120}}</ref> IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29 #MMPMID15699120 Siren J; Pirhonen J; Julkunen I; Matikainen S J Immunol 2005[Feb]; 174 (4): 1932-7 PMID15699120show ga Toll-like receptors (TLRs) mediate host cell activation by various microbial components. TLR2, TLR3, TLR4, TLR7, TLR8, and TLR9 are the receptors that have been associated with virus-induced immune response. We have previously reported that all these TLRs, except TLR9, are expressed at mRNA levels in human monocyte-derived macrophages. Here we have studied TLR2, TLR3, TLR4, and TLR7/8 ligand-induced IFN-alpha, IFN-beta, IL-28, and IL-29 expression in human macrophages. IFN-alpha pretreatment of macrophages was required for efficient TLR3 and TLR4 agonist-induced activation of IFN-alpha, IFN-beta, IL-28, and IL-29 genes. TLR7/8 agonist weakly activated IFN-alpha, IFN-beta, IL-28, and IL-29 genes, whereas TLR2 agonist was not able to activate these genes. IFN-alpha enhanced TLR responsiveness in macrophages by up-regulating the expression of TLR3, TLR4, and TLR7. IFN-alpha also enhanced the expression of TLR signaling molecules MyD88, TIR domain-containing adaptor inducing IFN-beta, IkappaB kinase-epsilon, receptor interacting protein 1, and IFN regulatory factor 7. Furthermore, the activation of transcription factor IFN regulatory factor 3 by TLR3 and TLR4 agonists was dependent on IFN-alpha pretreatment. In conclusion, our results suggest that IFN-alpha sensitizes cells to microbial recognition by up-regulating the expression of several TLRs as well as adapter molecules and kinases involved in TLR signaling. |Antiviral Agents/physiology[MESH] |Cell Line[MESH] |Cell-Free System/immunology[MESH] |Cells, Cultured[MESH] |Cytokines[MESH] |DNA-Binding Proteins/metabolism[MESH] |Gene Expression Regulation/*immunology[MESH] |Humans[MESH] |Influenza A virus/immunology[MESH] |Interferon Regulatory Factor-1[MESH] |Interferon-alpha/biosynthesis/genetics/*physiology[MESH] |Interferon-beta/biosynthesis/*genetics[MESH] |Interferon-gamma/biosynthesis[MESH] |Interferons[MESH] |Interleukins/biosynthesis/*genetics[MESH] |Ligands[MESH] |Macrophage Activation/immunology[MESH] |Macrophages/immunology/metabolism/virology[MESH] |Membrane Glycoproteins/agonists/biosynthesis/*physiology[MESH] |NF-kappa B/metabolism[MESH] |Phosphoproteins/metabolism[MESH] |Receptors, Cell Surface/agonists/biosynthesis/*physiology[MESH] |Sendai virus/immunology[MESH] |Signal Transduction/immunology[MESH] |Toll-Like Receptor 2[MESH] |Toll-Like Receptor 3[MESH] |Toll-Like Receptor 4[MESH] |Toll-Like Receptor 7[MESH] |Toll-Like Receptor 8[MESH] |Toll-Like Receptor 9[MESH]IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-be(epmc).pdf DeepDyve Pubget Overpricing