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10.1099/vir.0.80566-0 http://scihub22266oqcxt.onion/10.1099/vir.0.80566-0 15659759!ä!15659759 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gen+Virol 2005 ; 86 (Pt 2): 399-403 Nephropedia Template TP {{tp|p=15659759|t=2005. Vaccine-induced protection against Borna disease in wild-type and perforin-deficient mice |pdf=|usr=}}{{15659759}} gab.com Text Vaccine-induced protection against Borna disease in wild-type and perforin-deficient mice JO: J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=15659759 #FOAvip Borna disease virus (BDV) can persistently infect the central nervous system and induce CD8+ T-cell-mediated neurological disease in MRL mice. To determine whether specific immune priming would prevent disease, a prime-boost immunization protocol was established in which intramuscular injection of a recombinant parapoxvirus expressing BDV nucleoprotein (BDV-N) was followed by intraperitoneal infection with vaccinia virus expressing BDV-N. Immunized wild-type and perforin-deficient mice remained healthy after intracerebral infection with BDV and contained almost no virus in the brain at 5 weeks post-challenge. Immunization failed to induce resistance against BDV in mice lacking mature CD8+ T cells. Immunization of perforin-deficient mice with a poxvirus vector expressing mutant BDV-N lacking the known CD8+ T-cell epitope did not efficiently block multiplication of BDV in the brain and did not prevent neurological disease, indicating that vaccine-induced immunity to BDV in wild-type and perforin-deficient mice resulted from the action of CD8+ T cells. Twit Text FOAVip Vaccine-induced protection against Borna disease in wild-type and perforin-deficient mice ????J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=15659759 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15659759 #FOAvip English Wikipedia <ref>{{Cite pmid|15659759}}</ref> Vaccine-induced protection against Borna disease in wild-type and perforin-deficient mice #MMPMID15659759 Hausmann J; Baur K; Engelhardt KR; Fischer T; Rziha HJ; Staeheli P J Gen Virol 2005[Feb]; 86 (Pt 2): 399-403 PMID15659759show ga Borna disease virus (BDV) can persistently infect the central nervous system and induce CD8+ T-cell-mediated neurological disease in MRL mice. To determine whether specific immune priming would prevent disease, a prime-boost immunization protocol was established in which intramuscular injection of a recombinant parapoxvirus expressing BDV nucleoprotein (BDV-N) was followed by intraperitoneal infection with vaccinia virus expressing BDV-N. Immunized wild-type and perforin-deficient mice remained healthy after intracerebral infection with BDV and contained almost no virus in the brain at 5 weeks post-challenge. Immunization failed to induce resistance against BDV in mice lacking mature CD8+ T cells. Immunization of perforin-deficient mice with a poxvirus vector expressing mutant BDV-N lacking the known CD8+ T-cell epitope did not efficiently block multiplication of BDV in the brain and did not prevent neurological disease, indicating that vaccine-induced immunity to BDV in wild-type and perforin-deficient mice resulted from the action of CD8+ T cells. |*Borna disease virus/genetics/immunology[MESH] |*Vaccination[MESH] |Animals[MESH] |Borna Disease/immunology/*prevention & control/virology[MESH] |Brain/virology[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |Disease Models, Animal[MESH] |Drug Evaluation, Preclinical[MESH] |Epitopes, T-Lymphocyte/genetics/immunology[MESH] |Genetic Vectors[MESH] |Injections, Intramuscular[MESH] |Membrane Glycoproteins/deficiency/genetics[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Mutation[MESH] |Nucleoproteins/biosynthesis/genetics[MESH] |Parapoxvirus/genetics[MESH] |Perforin[MESH] |Pore Forming Cytotoxic Proteins[MESH] |Vaccines, Synthetic/administration & dosage[MESH] |Viral Proteins/biosynthesis/genetics[MESH]Vaccine-induced protection against Borna disease in wild-type and per(epmc).pdf DeepDyve Pubget Overpricing